| 铅暴露对学龄前儿童免疫球蛋白IgE影响的研究 |
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| 引用本文： | 孙鹂,赵正言,李荣,陈汉云. 铅暴露对学龄前儿童免疫球蛋白IgE影响的研究[J]. 微量元素与健康研究, 2001, 18(3): 27-29 |
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| 作者姓名： | 孙鹂 赵正言 李荣 陈汉云 |
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| 作者单位： | 1. 浙江省儿童医院,杭州,310012
2. 浙江大学医学院附属儿童医院,杭州,310012 |
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| 基金项目： | 浙江省卫生厅资金资助项目(2000A061) |
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| 摘 要： | 目的 :探讨低水平铅暴露对学龄前儿童免疫球蛋白 Ig E的影响。方法 :用石墨炉原子吸收光谱法对 2 1 7名学龄前儿童进行血铅浓度筛查 ,用酶联免疫吸附试验 ( ELISA)检测不同血铅水平对学龄前儿童免疫球蛋白 Ig E的影响。结果 :高铅组 (血铅≥ 0 .48μmol/L)学龄前儿童Ig E水平与低铅组 (血铅 <0 .48μmol/L)比较具有升高趋势 ,但无统计学意义 ( P>0 .0 5 ) ;高铅组血铅浓度与 Ig E水平呈正相关 ( r=0 .5 0 ,P<0 .0 1 ) ;女童高铅组 Ig E水平与低铅组比较显著升高 ( P<0 .0 5 )。结论 :铅中毒具有刺激学龄前儿童 Ig E的产生 ;铅暴露对学龄前儿童 Ig E水平的影响具有性别差异
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| 关 键 词： | 铅暴露 学龄前儿童 IgE |
| 文章编号： | 1005-5320(2001)03-0027-03 |
| 修稿时间： | 2001-03-09 |
Effect of Lead Exposure on immunoglobulin E In Preschool Children |
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| Sun Li,Zhao Zhengyan,Li Ron,Chen Hanyun. Effect of Lead Exposure on immunoglobulin E In Preschool Children[J]. Studies of Trace Elements and Health, 2001, 18(3): 27-29 |
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| Authors: | Sun Li Zhao Zhengyan Li Ron Chen Hanyun |
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| Abstract: | Objective:To study the effects of lead exposure on immunoglobulin E in preschool children.Methods:Blood lead levels were measured in 217 preschool children by graphite furnace atomic absorption spectrophotometry.and IgE of different blood lead levels were analysed by ELISA.Results:No statistically significant differences between groups of high and low blood lead levels were found (P>0 05).A statistically significant relationship of IgE and blood lead level was found in high blood lead group (r=0.50,P<0 01).IgE levels of female children were increased in the high blood lead level group (P<0 05).Conclusion:Low level lead exposure could play a role in this process by stimulating IgE prduction in children.The effect of lead on IgE was stronger in girls than in boys. |
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| Keywords: | Lead exposure Preschool children IgE |
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