| Eppin抗原的二级结构分析B细胞表位预测 |
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| 引用本文： | 李晋涛,陈正琼,梁志清,阎萍,何畏,吴玉章. Eppin抗原的二级结构分析B细胞表位预测[J]. 第三军医大学学报, 2008, 30(24): 2254-2257 |
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| 作者姓名： | 李晋涛 陈正琼 梁志清 阎萍 何畏 吴玉章 |
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| 作者单位： | 第三军医大学,基础医学部全军免疫学研究所;第三军医大学,西南医院妇产科,重庆,400038 |
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| 基金项目： | 国家科技支撑计划 ， 国家自然科学基金 |
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| 摘 要： | 目的 分析Eppin抗原的二级结构并预测其B细胞表位.方法 联合运用多种方法对Eppin的二级结构和表面特性,如亲水性、理化性质、可及性、免疫原性和可塑性等方面进行分析,预测其抗原表位.结果 Eppin存在多个潜在的抗原表位位点,可能的蛋白质抗原表位区域:14～23,30～44,48～54,56～68,78～85,97～106,109～116,125～132.体外实验证明,所预测抗原表位区域基本能与免疫抗血清发生抗原特异性反应.结论 应用多参数成功预测了Eppin抗原的B细胞表位.
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| 关 键 词： | Eppin抗原 B细胞 表位 |
Prediction of B cell epitope for Eppin antigen |
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| LI Jin-tao,CHEN Zheng-qiong,LIANG Zhi-qing,YAN Ping,HE Wei,WU Yu-zhang. Prediction of B cell epitope for Eppin antigen[J]. Acta Academiae Medicinae Militaris Tertiae, 2008, 30(24): 2254-2257 |
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| Authors: | LI Jin-tao CHEN Zheng-qiong LIANG Zhi-qing YAN Ping HE Wei WU Yu-zhang |
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| Affiliation: | LI Jin-tao1,CHEN Zheng-qiong2,LIANG Zhi-qing2,YAN Ping2,HE Wei2,WU Yu-zhang1 (1Institute of Immunology,College of Medicine,2Department of Obstetrics , Gynecology,Southwest Hospital,Third Military Medical University,Chongqing 400038,China) |
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| Abstract: | Objective To predict the B cell epitope for Eppin antigen. Methods The secondary structure and surface properties of Eppin, such as physical and chemical properties, hydrophilicity, accessibility, antigenicity and plasticity, were analyzed by a variety of methods. Results Many distinct antigenic epitopes in Eppin were identified by computation, the possible location of which is in the regions of 14-23, 30-44, 48-54, 56-68, 78-85, 97-106, 109-116, and 125-132. Conclusion The B cell epitope for Eppin is succe... |
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| Keywords: | Eppin antigen B cell epitope |
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