哮喘患者气道阻力变化对中枢驱动的影响

目的：了解哮喘患者气道阻力的变化对中枢驱动的影响。方法对１３例正常人和２１例哮喘患者作气道反应性测定，于激发试验前后分别测定吸气初０．１ｓ时口腔阻断压（０．０１），其中１０例哮喘患者激发试验后吸入喘乐宁，测定ＦＥＶ１及Ｐ０．１结果：正常人９名（９／１３）、哮喘患者１９例（１９／２１例）组胺激发试验后Ｐ０．１较激发前显著升高，两组Ｐ０．１升高人数的百分比比较差异无显著性，哮喘患者激发后ＦＥＶ１％与Ｐ

Changes of airway resistance and central drive in patients with asthma

Objective To study the effect of change in airway resistance on central drive in pa-tients with asthma. Methods Bronchial provocation tests were done in 13 normal subjects and 21 pa-tients with asthma. The mouth occlusion pressures at 0. 1 second at the beginning of inspiration(P_0.1 ) were measured before and after provocation. while FEV_1 and P_0. 1 were measured in 10 patientswho inhaled Artrovent after provocation. Results P_0.1 increased significantly in 9 normal subjects(9/13) and 19 patients (19/21 ) after provocation test. FEV_1 correlated negatively with P_0. 1 in pa-tients after provocation test (r = - 0. 4576 . P <0. 05 ). In 10 patients who inhaled Artrovent afterprovocation test, FEV_1 and P_0. 1 significantly increased and decreased, respectively. Conclusion Cen-tral drive may be influenced by airway resistance.