Altered biodistribution of an antibody--enzyme conjugate modified with polyethylene glycol. |
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| Authors: | E. A. Eno-Amooquaye F. Searle J. A. Boden S. K. Sharma P. J. Burke |
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| Affiliation: | Department of Medical Oncology, Charing Cross Hospital, London, UK. |
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| Abstract: | Polyethylene glycol modification of the antibody--enzyme conjugate, F(ab'')2-A5B7-CPG2, extends its duration in the circulation of nude mice bearing human colonic cancer xenografts (LS174T). Increased concentration of modified conjugate is achieved in the tumour, but residual non-specific enzyme concentrations in normal tissue and blood demonstrate the fundamental requirement to remove or inactivate non-specifically held enzyme in this system. |
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