In vitro anti-anaerobic activity of the cephalosporin derivative RWJ 54428, compared to seven other compounds |
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| Authors: | D B Hoellman L M Kelly M R Jacobs P C Appelbaum |
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| Institution: | Department of Pathology, Hershey Medical Center, PO Box 850, Hershey, PA 17033, USA;Department of Pathology, Case Western Reserve University, Cleveland, OH, USA;
Tel: +1 717 531 5113 Fax: +1 717 531 7953 E-mail: |
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| Abstract: | Agar dilution MIC was used to test the activity of RWJ 54428, a new cephalosporin derivative, compared to imipenem, meropenem, ceftriaxone, piperacillin, piperacillin–tazobactam, clindamycin and metronidazole against 363 anaerobes isolated from clinical specimens. RWJ 54428 had low MICs against most β -lactamase-negative Gram-negative rods, and all Gram-positive strains except Clostridium difficile . Imipenem and meropenem had the lowest MICs (MIC50s of 0.125 mg/L and MIC90s of 1.0 mg/L). Piperacillin–tazobactam, clindamycin and metronidazole were active against most strains, and ceftriaxone was active mainly against β -lactamase-negative organisms. |
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| Keywords: | Anaerobes MICs RWJ 54428 |
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