黑皮素4受体基因多态性与青少年肥胖的相关性研究

目的探讨黑皮素4受体(MC4R)基因V103I多态性与青少年肥胖、血脂的相关性,为控制肥胖提供理论依据。方法选择北京市东城区919名14~17岁初中生进行身体测量、血脂测定和V103I多态性检测。结果青少年各项血脂指标均表现为肥胖组>超重组>体重正常组(P<0.05),肥胖与血脂存在一定相关性;V103I等位基因突变率(G>A)为3.9%;体重正常、超重和肥胖组之间基因型构成和等位基因频率差异无统计学意义(P>0.05);男性超重组GG基因型的腰臀比(WHR)略低于GA/AA基因型(P<0.05);血脂指标TC,TG,LDL-C异常者与正常者相比,基因型构成和等位基因频率差异无统计学意义。结论中国青少年MC4R基因V103I多态性突变率与白种人接近,该多态性可能与男性超重有关,但与血脂异常没有显著关联。

Study on the Relationship Between Melanocortin 4 Receptor(MC4R) Gene Polymorphism and Obesity or Serum Lipids in Adolescents

Objective To study the relationship between melanocortin 4 receptor(MC4R) gene V103I polymorphism and obesity or serum lipids in Chinese adolescents,and to provide theoretical evidence for obesity centrol.Methods Altogether 919 middle school students were selected from Dongcheng District,Beijing.Physical examination,serum lipids level and the MC4R gene V103I polymorphism were performed for all subjects.Results The levels of TC,TG and LDL-C were different among three groups: obese group>overweight group>normal-weight group(P<0.05),indicating association between obesity and serum lipids. Mutation rate of allele was 3.9% for V130I.The differences of genotype and allele frequencies were not statistically significant among the three groups(P>0.05).However,in males of the overweight group,the subjects of GG genotype exhibited lower WHR than GA/AA carriers(P<0.05).There was no statistical significance between individuals with normal serum lipids(TC,TG,LDL-C) and abnormal ones for genotype and allele frequencies.Conclusion The frequency of MC4R gene V103I polymorphism in Chinese adolescents is similar to that of Caucasians.The polymorphism may be associated with male overweight,but there is no significant association between the polymorphism and abnormal serum lipids.