动态检测血清白介素-18对急性胰腺炎病情及预后评价的意义

目的 探索急性胰腺炎患者血清中自介素-18(IL-18)水平变化情况,及其与患者入院时APACHE Ⅱ评分及患者预后之间的关系.方法 按照急性胰腺炎的临床诊断及分级标准分组选择AP患者34例,其中重症胰腺炎(SAP)患者12例,轻型急性胰腺炎(MAP)患者22例,正常对照组16例.用ELISA法检测血清IL-18浓度.结果 血清中IL-18浓度在MAP和SAP两组患者之间均存在统计学差异(P<0.01),SAP组明显高于MAP组,且IL-18水平动态变化与APACHEⅡ评分呈正相关.结论 血清IL-18参与了急性胰腺炎的炎症反应过程,可以作为预测急性胰腺炎严重程度的指标.

Dynamic change and prognostic significance of serum IL-18 in a-cute pancreatitis

Objective To study the dynamic change and prognostic significance of serum IL-18 in acute pancreatitis,and to explore the relationship between the APACHE Ⅱ score and prognosis of. Acute pancreati-tis. Methods According to the clinical diagnosis and criteria for acute pancreatitis, 34 patients with AP were divided into severe acute pancreatitis (SAP) group( n = 12 ) and mild acute pancreatitis (MAP) group (n = 22). Sixteen normal individuals were used as the control group ( n = 16.). The serum IL-18 was detected by ELISA. Results IL-18 in the SAP group was higher than that in the MAP group. In the MAP group, there was significant positive correlation between APACHE Ⅱ and IL-18 ( r = 0.98 ,P < 0.01 ). Conclusion IL-18 plays an important role in the development of acute pancreatitis, and it may be a valuable index to predict the severity of AP.