Molecular cloning and sequencing of the La Crosse virus S RNA |
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| Authors: | C D Cabradilla B P Holloway J F Obijeski |
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| Affiliation: | 1. Dept. of Microbiology and Hygiene, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium;2. Vrije Universiteit Brussel, and Department of Electron Microscopy, Pasteur Instituut van Brabant, Stoomslepersstraat 28, 1040 Brussels, Belgium |
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| Abstract: | The neutralization of type 1 poliovirus by a monoclonal antibody was studied. The antibody caused polymerization of the virions as observed by sucrose gradient centrifugation and electron microscopy. Dimers, trimers, and higher polymers were formed. No antibody was found in association with the monomeric virions remaining after neutralization, which retained full infectivity. The specific infectivities of dimers, trimers, and higher polymers decreased in that order. |
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| Keywords: | Author to whom reprint requests should be addressed. |
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