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Neuropsychiatric aspects of HIV-1 infection in gay men: Controlled investigation of psychiatric, neuropsychological and neurological status |
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| Authors: | Massimo Riccio Kathryn Pugh Danitza Jadresic Adrian Burgess Christopher Thompson Barbara Wilson Ella Lovett Torsten Baldeweg David A. Hawkins Jose Catalan |
| Affiliation: | a Academic Department of Psychiatry, Charing Cross and Westminster Medical School, Chelsea, USA b Westminster Hospital, 369 Fulham Rd, London SW10, U.K. c University Department of Psychiatry, Manchester Royal Infirmary, U.K. d Department of Psychiatry, Royal South Hants Hospital, Southampton, U.K. e MRC Applied Psychology Unit, 15 Chaucer Rd, Cambridge, U.K. f St Stephens Clinic, Department of Genito-urinary Medicine, Chelsea, USA g Westminster Hospital, 369 Fulham Rd, London SW10, U.K. |
| Abstract: | The aim of this study was to determine whether HIV infection is associated with psychiatric morbidity or neuropsychological impairment in asymptomatic and early symptomatic stages of disease in gay men. The subjects were 100 gay men (68 HIV − ve, 32 HIV + ve, 6 being CDC IV). All subjects were recruited at the time of requesting their first HIV test and the assessment was double-blind to HIV serostatus. There were no differences in psychiatric status or neuropsychological performance between the HIV − ve and HIV + ve groups. Multiple regression analysis and logistic regression were used to identify factors associated with psychiatric morbidity, neuropsychological impairment and subjective reporting of memory problems and physical symptoms for all 100 subjects. Previous psychiatric history and current illegal (non-dependent) drug use were associated with psychiatric morbidity, poor education was assciated with neuropsychological impairment and psychiatric status (score on HAD and PSE) was associated with subjective reporting of memory problems and physical symptoms. |
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