| 血竭聚乳酸缓释微球的制备及体外释药研究 |
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| 引用本文： | 丁里玉 夏鹏飞,杨彩琴,林玉龙,王静. 血竭聚乳酸缓释微球的制备及体外释药研究[J]. 中国中药杂志, 2007, 32(5): 388-390 |
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| 作者姓名： | 丁里玉 夏鹏飞 杨彩琴 林玉龙 王静 |
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| 作者单位： | 河北医科大学,药学院,无机物化教研室,河北,石家庄,050017 |
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| 摘 要： | 目的：制备血竭聚乳酸缓释微球,并对其体外释药特性进行考察。方法：以聚乳酸为载体,采用乳化溶剂挥发法制备血竭聚乳酸O/W型缓释微球,考察了微球的粉粒学特征,并进行了体外溶出研究。结果：所制备的血竭聚乳酸微球外形圆整,载药量为21.97%,包封率为55.76%,16 h体外累积释药量为76.71%。结论：血竭聚乳酸微球具有很好的缓释能力,使用前景广阔。
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| 关 键 词： | 血竭 聚乳酸 缓释微球 体外释放 |
| 文章编号： | 1001-5302（2007）05-0388-03 |
| 收稿时间： | 2005-10-01 |
| 修稿时间： | 2005-10-01 |
Preparation and evaluation of sustained-release microsphere ofSanguis Draconis in vitro |
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| DING Li-yu; XIA Peng-fei; YANG Cai-qin; LIN Yu-long; WANG Jing. Preparation and evaluation of sustained-release microsphere ofSanguis Draconis in vitro[J]. China Journal of Chinese Materia Medica, 2007, 32(5): 388-390 |
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| Authors: | DING Li-yu XIA Peng-fei YANG Cai-qin LIN Yu-long WANG Jing |
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| Affiliation: | Department of Inorganic and Physical Chemistry,College of Pharmacy Hebei Medical University, Shijiazhuang 050017, China |
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| Abstract: | Objective: To prepare sustained-release microsphere containing extract of Sanguis Draconis and to measure its dissolution in vitro. Method: Sustained-release microsphere was prepared with polylactic acid (PLA) as carriers using the oil-in-water (O/W) emulsion solvent evaporation method. The powder particle's characteristics of sustainded-release microsphere were evaluated comprehensively, and its dissolution characteristics in vitro were studied. Result: The microsphere was round and its surface was smooth, drug-loading rate was 21.97% and the entrapment rate was 55.76%, the accumulative release percentage was 76.71% in 16 hours. Conclusion: The sustained release effect of Sanguis Draconis microspheres was formed with potentially wide applications. |
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| Keywords: | Sanguis Draconis polylactic acid sustained-release microsphere release behavior in vitro |
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