| 小檗碱对颈动脉粥样硬化家兔颈动脉病理改变和VCAM-1转录水平的影响 |
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| 引用本文： | 王建,何国厚,刘勇. 小檗碱对颈动脉粥样硬化家兔颈动脉病理改变和VCAM-1转录水平的影响[J]. 神经损伤与功能重建, 2009, 4(2) |
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| 作者姓名： | 王建 何国厚 刘勇 |
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| 作者单位： | 富阳市人民医院神经内科,浙江,富阳,311400;郧阳医学院附属太和医院神经内科,湖北十堰,432000 |
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| 摘 要： | 目的:探讨小檗碱预防颈动脉粥样硬化形成的作用机制。方法:将24只雄性新西兰大白兔随机分为对照组、模型组和小檗碱组各8只。对照组给予普通饮食;模型组和小檗碱组给予高脂饲料喂养1周后行右侧颈动脉内膜空气干燥术,术后,前者继续高脂饲料喂养4周以制成颈动脉粥样硬化模型,后者在前者的基础上每日灌服小檗碱(100 mg/kg)。第5周麻醉处死,取右侧颈动脉组织,行HE染色观察颈动脉病理改变,采用RT-PCR法测定VCAM-1 mRNA含量。结果:与对照组比较,模型组颈动脉内膜明显增生,内膜下可见大量泡沫细胞堆积,有明显粥样硬化斑块形成;而小檗碱组内膜轻度增厚,内膜下仅有少量泡沫细胞。模型组、小檗碱组和对照组VCAM-1/-βactin扩增带吸光度比值依次降低,差异有统计学意义(0.61±0.11,0.20±0.04,0.81±0.11,P<0.01)。结论:小檗碱可能通过抑制VCAM-1的表达预防颈动脉粥样硬化的形成。
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| 关 键 词： | 小檗碱 动脉粥样硬化 血管细胞粘附分子-1 |
The Effect of Berberine on the Expression of VCAM-1 in Rabbits with Carotid Artery Atherosclerosis |
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| WANG Jian,HE Guo-hou,LIU Yong. The Effect of Berberine on the Expression of VCAM-1 in Rabbits with Carotid Artery Atherosclerosis[J]. Neural Injury and Functional Reconstruction, 2009, 4(2) |
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| Authors: | WANG Jian HE Guo-hou LIU Yong |
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| Affiliation: | WANG Jian,HE Guo-hou,LIU Yong.Department of Neurology,The People's Hospital of Fuyang,Fuyang 311400,China |
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| Abstract: | Objective:To investigate the mechanisms of berberine of preventing atherosclerosis(AS) in rabbits.Methods:New Zealand white rabbits(n=24) were randomly divided into control,carotid artery atherosclerosis and berberine treatment groups(n=8 for each).The rabbits of the control group were fed with normal diets.Carotid atherosclerosis was established by an air-drying operation performed on the right common carotids.The rats with carotid artery atherosclerosis received a high cholesterol-diet at the second week ... |
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| Keywords: | berberine atherosclerosis vascular cell adhesion molecule-1 |
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