Synthesis of 3-aryl-5-decapentyl-1,2,4-oxadiazoles possessing antiinflammatory and antitumor properties |
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Authors: | Bezerra Natércia M Miranda De Oliveira Shalom P Srivastava Rajendra M Da Silva Joel R |
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Affiliation: | Departamento de Química Fundamental, Centro de Ciencias Exatas e de Natureza, Universidade Federal de Pernambuco, CEP 50740-540 Recife, PE, Brazil. |
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Abstract: | A simple, convenient and straightforward synthesis of 3-aryl-1,2,4-oxadiazoles 4a-f from arylamidoximes 1a-f and palmitic acid 2 is described. Compounds 4a-f are non-lethal in mice at four times the therapeutic dose (i.p., LD50>1 g kg(-1) of the animals' body weight). These heterocycles have been found to possess antiinflammatory property similar to aspirin and ibuprofen. Three compounds, viz., 4a, d, e have also been evaluated for antitumor activity, where 4d exhibited an excellent activity comparable to lapachol. |
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