New antimicrobial flavonoids and chalcone from <Emphasis Type="Italic">Colutea armata</Emphasis> |
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| Authors: | Farah Inamullah Itrat Fatima Sadia Khan Mehdi Hassan Kazmi Abdul Malik Rasool Bakhsh Tareen Tanveer Abbas |
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| Institution: | 1.Department of Applied Chemistry,University of Karachi,Karachi,Pakistan;2.International Centre for Chemical and Biological Sciences, HEJ Research Institute of Chemistry,University of Karachi,Karachi,Pakistan;3.Department of Botany,Balochistan University,Quetta,Pakistan;4.Department of Microbiology,University of Karachi,Karachi,Pakistan |
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| Abstract: | Colucins A (1) and B (2), new flavonoids and colucone (3), the new chalcone derivative, have been isolated from the CHCl3-soluble fraction of the whole plant of Colutea armata along with luteolin (4), luteolin 7-O-β-D-glucoside (5), isoliquiritigenin (6), trans-caffeic acid (7) and stigmasterol (8) reported for the first time from this species. Their structures were elucidated by spectroscopic techniques including MS and 2D-NMR spectroscopy. Compounds 1 and 2 showed significant antimicrobial activity against two Gram positive and three Gram negative bacterial strains while 3 was moderately active. |
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