| 怒 恐伤气大鼠血浆ACTH CORT IL-2 IL-8变化的比较研究 |
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| 引用本文： | 刘晓伟,曲宏达,张红梅,解亚宁,董秋安,许丽,许文学,邓虹珠,傅江南,李晓明.怒 恐伤气大鼠血浆ACTH CORT IL-2 IL-8变化的比较研究[J].辽宁中医杂志,2006,33(2):239-240. |
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| 作者姓名： | 刘晓伟 曲宏达 张红梅 解亚宁 董秋安 许丽 许文学 邓虹珠 傅江南 李晓明 |
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| 作者单位： | 南方医科大学中医系临床基础教研室,广东,广州,510515 |
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| 基金项目： | 国家自然科学基金资助项目(30271567)，广东省中医药管理局基金资助项目(02102074) |
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| 摘 要： | 目的:比较分析怒、恐伤气大鼠内分泌、免疫变化产生差异性的机理。方法:根据M egan E与Takash i方法制作怒、恐应激动物模型,采用放免方法,检测愤怒和恐惧应激后大鼠血浆促肾上腺皮质激素(ACTH)、血清皮质醇(CORT)、白细胞介素2(IL-2)和白细胞介素8(IL-8)的含量。将实验组与实验组、实验组与正常组进行对照。结果:恐惧组、愤怒组与正常对照组ACTH、CORT有显著性差异(P<0.05,P<0.01),IL-2有显著性差异(P<0.01);恐惧组ACTH与IL-2明显高于愤怒组(P<0.01):IL-8水平各组无显著性差异(P>0.05)。结论:愤怒、恐惧不同情志导致气机紊乱病机有别,对内分泌、免疫影响亦不同。
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| 关 键 词： | 愤怒 恐 内分泌 免疫 对照观察 |
| 文章编号： | 1000-1719(2006)02-0239-02 |
| 修稿时间： | 2005年9月22日 |
Compare of ACTH CORT IL-2 H-8 in Serum in Rats with Qi Injured by Anger and Fear |
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| LIU Xiao-wei,QU Hong-da,ZHANG Hong-mei,XIE Ya-ning,DONG Qiu-an,XU Li,XU Wen-xue,DENG Hong-zhu,FU Jiang-nan,LI Xiao-ming.Compare of ACTH CORT IL-2 H-8 in Serum in Rats with Qi Injured by Anger and Fear[J].Liaoning Journal of Traditional Chinese Medicine,2006,33(2):239-240. |
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| Authors: | LIU Xiao-wei QU Hong-da ZHANG Hong-mei XIE Ya-ning DONG Qiu-an XU Li XU Wen-xue DENG Hong-zhu FU Jiang-nan LI Xiao-ming |
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| Abstract: | Objective:Compare and analyze the diversity of endocrine and immunity in rats with Qi injured by Anger and Fear.M ethods:Animal models were established according to Megan E and Takashi's methods respectively.Serum adrenocorticotropic hormone(ACTH),cortisol(CORT),interleuking(IL)-2,IL-8 were analyzed through RIA.Compare anger group and fear group,model groups and normal group.Results:Anger and fear could significantly increase the level of ACTH and CORT in plasma(P<0.05,P<(0.01)),reduce IL-2(P<(0.01)).The level of ACTH and IL-2 in fear group are higher than that of anger group significantly(P<(0.01)).IL-8 in each group have no significant discrepancy(P>(0.05)).Conclusion:Qi injured by anger and fear have different form and influence on endocrine-immunity. |
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| Keywords: | anger fear endocrine immunity |
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