| 基于斑马鱼模型的药物毒性研究进展与中药毒性研究新策略 |
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| 引用本文： | 彭蕴茹,韦英杰,丁永芳,段金廒. 基于斑马鱼模型的药物毒性研究进展与中药毒性研究新策略[J]. 中草药, 2017, 48(1): 17-30 |
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| 作者姓名： | 彭蕴茹 韦英杰 丁永芳 段金廒 |
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| 作者单位： | 南京中医药大学附属中西医结合医院, 江苏 南京 210014;江苏省中医药研究院, 江苏 南京 210028;南京中医药大学 江苏省方剂高技术研究重点实验室/江苏省中药资源产业化过程协同创新中心, 江苏 南京 210023;南京中医药大学附属中西医结合医院, 江苏 南京 210014;江苏省中医药研究院, 江苏 南京 210028;南京中医药大学附属中西医结合医院, 江苏 南京 210014;江苏省中医药研究院, 江苏 南京 210028;南京中医药大学 江苏省方剂高技术研究重点实验室/江苏省中药资源产业化过程协同创新中心, 江苏 南京 210023 |
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| 基金项目： | 国家重点基础研究发展计划（“973计划”）项目：基于“十八反”的中药配伍禁忌理论基础研究（2011CB505300）；国家重点基础研究发展计划（“973计划”）项目：“藻戟遂芫俱战草”配伍关系与毒效表征的基础研究（2011CB505303）；国家自然科学基金项目（81573833）：基于三维M-Act/Tox协同评价的抗骨质疏松中药筛选新方法的建立与应用（81573833）；基于肝脏炎症-肝纤维化-肝癌轴的白首乌生物学行为研究（81373888）；江苏省方剂高技术研究重点实验室/江苏省中药资源产业化过程协同创新中心资助项目：海藻类中药与甘草配伍禁忌特征及其内在规律性的拓展研究（FJGJS-2015-05） |
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| 摘 要： | 斑马鱼是近年来用于药学领域研究的热门模式生物,其优势在于化合物的高通量活性筛选及毒性评价。斑马鱼毒性评价模型集成在体动物与体外细胞模型的优势,具有高效、低成本的特点,在国外已成为化合物早期安全性快速甄别的有效模型,国内将斑马鱼模型用于中药毒性研究正日益兴起。综述了斑马鱼在药物毒性研究方面的进展,提出斑马鱼模型在中药毒性研究中的新策略。
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| 关 键 词： | 斑马鱼 斑马鱼毒性评价模型 药物毒性 中药毒性 模式生物 |
| 收稿时间： | 2016-07-12 |
Development of drug toxicity and novel strategy for toxicity of Chinese materia medica based on zebrafish model |
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| PENG Yun-ru,WEI Ying-jie,DING Yong-fang and DUAN Jin-ao. Development of drug toxicity and novel strategy for toxicity of Chinese materia medica based on zebrafish model[J]. Chinese Traditional and Herbal Drugs, 2017, 48(1): 17-30 |
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| Authors: | PENG Yun-ru WEI Ying-jie DING Yong-fang DUAN Jin-ao |
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| Affiliation: | Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210014, China;Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, China;Jiangsu Province Key Laboratory for High Technology Research of TCM Formulae and Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing 210023, China;Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210014, China;Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, China;Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210014, China;Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, China;Jiangsu Province Key Laboratory for High Technology Research of TCM Formulae and Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing 210023, China |
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| Abstract: | With the advantages of high throughput activity screening and toxicity evaluation, zebrafish has become popular model organism in pharmaceutical research in recent years. Being integrated advantages both in vivo and in vitro, with high efficiency and low cost, evaluation using zebrafish has become an effective method in quick screening of early safety of compounds on abroad. In past years, studies on toxicity of traditional Chinese medicine (TCM) with zebrafish model have attracted more attention in China. The development in drug toxicity studies based on zebrafish model was reviewed, and novel strategy for toxicity of TCM using zebrafish was suggested in the paper. |
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| Keywords: | zebrafish toxicity assessment of zebrafish model drug toxicity toxicity of Chinese materia medica model organism |
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