2型糖尿病肾病患者超敏C反应蛋白的测定及分析

目的比较2型糖尿病及糖尿病肾病患者的血浆超敏C反应蛋白（hs CRP）的水平。方法检测对象分3组,A组：2型糖尿病组DM（＋）,UAlb〈30mg/24h,n=32];B组：糖尿病肾病组DM（＋）,UAlb≥30mg/24h,n=30];C组：健康对照组DM（-）,UAlb〈30mg/24h,n=30],均测定血清CRP的含量,同时测定血浆胰岛素（INS）、空腹血糖（FBG）、总胆固醇（CHO）、高密度脂蛋白胆固醇（HDL-CHO）、低密度脂蛋白胆固醇（LDL-CHO）、甘油三脂（TG）、糖化血红蛋白（GHbA1C）和HOMA-IR指数。结果A组和B组hs-CRP明显高于C组（P〈0.01）;B组hs-CRP也明显高于A组;且糖尿病患者hs-CRP与糖化血红蛋白（GHbA1c）,空腹血浆胰岛素（INS）和HOMA IR指数之间存在正相关。结论血清CRP与2型糖尿病及其血管并发症密切相关,2型糖尿病患者的hs-CRP与HbA1c、空腹血浆胰岛素和HOMAIR之间存在正相关,因此炎症、高血糖、胰岛素抵抗增加了2型糖尿病患者血管并发症危险。

Test and Analysis of Serum High Sensitive C-reactive Protein in Patients with Type 2 Diabetic Nephropathy

Objective To compare serum high Sensitive C-reactive protein （hs-CRP） levels in Type 2 diabetes mellitus （T2DM） and type 2 diabetic nephropathy. Methods All patients were divided into three groups ： Group A DM （ ＋ ）, UAlb 〈 30 mg/24 h, n =32] ,Group B DM（ ＋ ） ,UAlb≥30 mg/24 h,n = 30] ,Group C Normal health subjects,n = 30]. The serum hs-CRP,insulin, glucose,total cholesterol, HDL-CHO, LDL-CHO, TG, HbAlC and Homeostasis model assessment for insulin resistance （ HOMA IR） index were determined. Results The mean hs-CRP levels of Group A and Group B were higher than that of Group C （ P 〈0.01 ） ;Mean hs-CRP levels of Group B was higher than that of Group A（ P 〈0.05 ）. The hs-CRP levels of Type 2 diabetic has a positive correlation with HbA1 C, fasting insulin and HOMA-IR. Conclusions Increased level of serum CRP may correlate with type 2 diabetes and its angiopathy. There was positive correlation between serum hs-CRP and HbA1 c, fasting insulin and HOMA- IR in patients with T2DM. The inflammation, hyperglycaemia and insulin resistance contribute jointly to angiopathy in T2DM patients.