| 脊髓损伤早期神经细胞C-fos基因表达及其意义 |
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| 引用本文： | 白伦浩,高红,王海义,陈淑珍.脊髓损伤早期神经细胞C-fos基因表达及其意义[J].中国医科大学学报,2003,32(6):511-512. |
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| 作者姓名： | 白伦浩 高红 王海义 陈淑珍 |
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| 作者单位： | 1. 中国医科大学附属第二医院骨科,辽宁,沈阳,110004
2. 小儿外科实验室 |
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| 摘 要： | 目的：从分子水平探讨脊髓损伤发病机制，为临床治疗脊髓损伤寻求有效手段。方法：选用Wistar大鼠30只，制造脊髓压迫性损伤模型，以免疫组织化学方法，动态观察大鼠脊髓损伤早期神经细胞C-fos基因表达变化。结果：脊髓损伤后2h，损伤区胶质细胞中C-fos基因表达已明显，伤后6，8，24h更为显著。结论：脊髓损伤后C-fos基因表达的情况可能与脊髓原发性损伤和继发性损伤机制有关。
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| 关 键 词： | 脊髓损伤 C-fos基因 |
| 文章编号： | 0258-4646(2003)06-0511-02 |
| 修稿时间： | 2003年5月12日 |
Expression and Significance of C-fos Gene in Nerve Cells in Early Stage of Spinal Cord Injury |
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| BAI Lun hao ,GAO Hong ,WANG Hai yi ,CHEN Shu zhen.Expression and Significance of C-fos Gene in Nerve Cells in Early Stage of Spinal Cord Injury[J].Journal of China Medical University,2003,32(6):511-512. |
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| Authors: | BAI Lun hao GAO Hong WANG Hai yi CHEN Shu zhen |
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| Institution: | BAI Lun hao 1,GAO Hong 2,WANG Hai yi 1,CHEN Shu zhen 1 |
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| Abstract: | Objective: Our aims were to study the mechanism of spinal cord injury at molecular level and to explore the effective methods for treatment of spinal cord injury (SCI). Methods: Animal models of SCI were established in 30 Wistar rats. Changes of C fos gene expression in nerve cells were observed with immunohistochemical methods in the early stage of SCI. Results: Expression of C fos gene in glicial cells of injuried areas was obvious 2 hours after SCI, and more significant 6, 8, and 24 hours after the injury. Conclusion: The phases of C fos gene expression after SCI were closely related to the mechanism of primary and secondary injury. |
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| Keywords: | spinal cord injury C fos gene |
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