妊娠期糖尿病患者并发高血压与胰岛素抵抗的关系

目的：探讨妊娠期糖尿病患者并发高血压与其胰岛素敏感性的关系。方法：血糖筛查阳性孕妇95例分为高血压疾病组和血压正常组，口服葡萄糖耐量试验后，比较2组孕妇血糖BG1、BG2、BG3、空腹胰岛素测定值及胰岛素敏感性，并以健康体检合格孕妇85名为对照组。结果：高血压疾病组空腹血糖、服糖1、2．3h后的血糖、空腹胰岛素测定值均高于血压正常组和对照组，差异有显著性（P〈0．05），胰岛素敏感指数降低高于血压正常组及对照组（P〈0．05）。结论：妊娠期糖尿病患者存在明显的胰岛素抵抗，其晚期发生妊高征的可能性较大。

Relationship Between Blood Pressure and Insulin Resistance in Patients with Gestational Diabetes

Objective To study the relationship existe between blood pressure level and degree of insulin resistance in patients with gestational diabetes.Methods Ninety-five cases of gestational diabetes were diagnosed among 350 pregnant women.Of them,55 were found to be hypertensive and 40 were normotensive.Fasting,1,2,3h post-prandial(75g glucose) blood sugar(with peroxidase method) levels and fasting insulin(with RIA) levels were measured in these patients and 85 normal pregnant women(as control).Results Fasting,1,2,3h post 75g glucose blood sugar and fasting insulin levels in the 55 hypertensive diabetics were significantly higher than those in the normotensives and controls(P<0.05).The calculated insulin sensitivity indices were significantly lower(P also <0.05).Conclusion A higher insulin resistance existed in hypertensive gestational diabetics which might be a risk factor of developing hypertension.