HIV/AIDS患者合并宫颈癌与癌前病变的影响因素分析

目的探讨艾滋病病毒（HIV）感染者和艾滋病（AIDS）患者合并宫颈癌与癌前病变的相关影响因素。方法以在本院诊治的40例HIV/AIDS（HIV抗体阳性）合并宫颈癌与癌前病变患者为观察组,等距抽样选择同期在本院诊治的40例HIV抗体阴性宫颈癌与癌前病变患者为对照组,对其相关危险行为、宫颈癌与癌前病变的程度进行横断面调查。结果观察组中HIV感染者19例（47.50%）, AIDS患者21例（52.50%）；两组多性伴、性病史、配偶/固定性伴有多性伴、配偶/固定性伴HIV抗体阳性差异具有高度统计学意义（45.00%比10.00%、37.50%比7.50%、82.50%比27.50%、72.50%比2.50%, P均〈0.01）；两组宫颈病变不同程度中CINⅢ与宫颈癌的发生率差异具有高度统计学意义（57.50%比15.00%与27.50%比2.5%, P均〈0.01）, CINⅡ的发生率与孕次≥3次比较差异无统计学意义（15.00%比32.50%,65.00%比50.00%）。结论 HIV/AIDS患者合并宫颈癌与癌前病变的影响因素与多性伴、性病史、配偶/固定性伴有多性伴、配偶/固定性伴HIV抗体阳性密切相关；HIV抗体阳性者CIN Ⅲ与宫颈癌的发生率显著高于HIV抗体阴性者。

Analysis on influence factors of cervical cancer/precancerous lesions on patients with HIV/AIDS PANG

Objective To explore the related influence factors of cervical cancer/precancerous lesions on patients with HIV/AIDS. Methods Took 40 cases of inpatients with HIV/AIDS（HIV-positive） and with cervical cancer /precancerous lesions as observation group, chose 40 cases of HIV-negative inpatients with cervical cancer/precancerous lesions for the period by interval sampling. Investigated them on cross section by related risky behaviors and the levels of cancer/precancerous lesions. Results For the observation group, there were 19 HIV-infected cases（47.50%） and 21 others AIDS patients（52.50%）. Between the two group there was highly significant difference among factors of multiple sexual partner, venereal history, multiple sexual partner for spouse/regular sex partner, HIV-positive spouse/regular sex partner（45.00%VS 10.00%、37.50%VS 7.50%、82.50%VS 27.50%、72.50%VS 2.50%,P〈0.01）. On different levels of cervical lesions, there was highly significant difference in incidence of cervical cancer for patients with CIN III while with CIN II and gravidity more than 3 times, there’s no significant difference（15.00%VS 32.50%,65.00%VS 50.00%）. Conclusion The influence factors of closely related with multiple sexual partner, venereal history, multiple sexual partner for spouse/regular sex partner, HIV-positive spouse/regular sex partner. The incidence of cervical cancer for patients with CIN III is higher than those with HIV-negative.