| 心肌缺血模型大鼠气虚证相关信息的评价 |
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| 引用本文： | 仇琪,王勇,李春,陈婵,郭淑贞,王伟. 心肌缺血模型大鼠气虚证相关信息的评价[J]. 中华中医药杂志, 2010, 0(2) |
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| 作者姓名： | 仇琪 王勇 李春 陈婵 郭淑贞 王伟 |
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| 作者单位： | 北京中医药大学; |
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| 基金项目： | 国家重点基础研究发展计划(973计划)(No.2003CB517105);;国家科技重大专项课题(No.2009ZX09502)~~ |
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| 摘 要： | 目的:探究心肌缺血模型大鼠的证候属性,对模型大鼠气虚证相关信息进行客观评价。方法:采用左冠状动脉结扎法复制大鼠心肌缺血模型,术后多个时间点,动态观察大鼠宏观体征,计算安静状态下呼吸频率、应激后呼吸频率和游泳力竭时间,采用超声心动法,评价术后各时间点大鼠心功能。结果:模型组大鼠术后7-60d,安静状态下呼吸频率下降,应激后呼吸频率增加;心功能明显下降;术后8-29d,模型组大鼠游泳力竭时间明显缩短。结论:左冠状动脉结扎法造成的心肌缺血大鼠在术后7-60d内同时具备血瘀证和气虚证相关指证。
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| 关 键 词： | 心肌缺血 气虚证 大鼠 动物模型 |
Evaluation of relevant informations in myocardial ischemic rats with qi-deficiency syndrome |
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| QIU Qi,WANG Yong,LI Chun,CHEN Chan,GUO Shu-zhen,WANG Wei. Evaluation of relevant informations in myocardial ischemic rats with qi-deficiency syndrome[J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2010, 0(2) |
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| Authors: | QIU Qi WANG Yong LI Chun CHEN Chan GUO Shu-zhen WANG Wei |
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| Affiliation: | Beijing University of Chinese Medicine;Beijing 100029;China |
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| Abstract: | Objective: To investigate the syndrome property of myocardial Ischemic, and evaluate the relevant informations of qi-deficiency. Methods: SD rats were subjected to either proximal LAD ligation or sham operation. The respiratory rate in both resting state and post-stress were counted. 20 rats (10 in each group) were subjected to forced swimming test (FST) to measure the exhaustive swimming time in every time point Echocardiography was used to evaluate the cardiac function in rats at each time point. Results:... |
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| Keywords: | Myocardial ischemic Qi-deficiency Rat Aninal model |
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