产超广谱β-内酰胺酶的大肠埃希菌检测及其药敏结果分析

目的了解某院产超广谱β-内酰胺酶(ESBLs)大肠埃希菌的检出及耐药情况。方法采用微生物生化、药敏试验卡,超广谱β-内酰胺酶试验卡及纸片扩散法对32例大肠埃希菌标本进行ESBLs检测,并对其药敏试验结果进行分析。结果从32株大肠埃希菌中经过确认试验,共检出产ESBLs大肠埃希菌8株,检出率为25.0%。药敏试验耐药率高,敏感性较高的只有美洛培南、哌拉西林/他唑巴坦等抗菌药物。结论产ESBLs的大肠埃希菌检出率较高,对大多数抗菌药物呈现多重耐药,需引起临床的高度重视。

ESBLs- producing Escherichia coli and Its Drug Susceptibility Profiles

Objective To analysis the antibiotic resistant patterns and isolates of E.coli that producing extended-spectrum beta-lactamases(ESBLs) in our hospital. Methods Thirty-two E.coli isolates in our hospital were tested with test cards for biochemical identification and antibiotic susceptibility.Isolates that produced ESBLs were detected by test card for extended-spectrum beta-lactamase and plate diffusion method.The results of antibiotic susceptibility were analyzed. Results Out of the 32 isolates of E.coli,8 strains yielded ESBLs(25.0%).These strains with ESBLs were highly resistant to most common available antibiotics, but only sensitive to Meropenem,Piperacillin/Tazobactam. Conclusion The test results showed that the isolates of E.coli with ESBLs were high.E.coli with ESBLs exhibited highly cross-resistant to a wide range of antibiotic drugs.Therefore,it is very important to identify these strains with ESBLs for the clinical treatment.