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Renin substrate in human amniotic fluid |
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| Authors: | Kaj Metsrinne Frej Fyhrquist Katarina Rosenlf Matti Autero Fredrika Pekonen Eeva-Marja Rutanen |
| Institution: | 1 Minerva Institute for Medical Research, Finland 2 IVth Department of Medicine, Helsinki University Central Hospital, Finland 3 Department of Biochemistry, University of Helsinki, Helsinki, Finland 4 Department of Biochemistry, Jorvi Hospital Espoo, Finland |
| Abstract: | Purified human amniotic fluid renin substrate (RS) was compared to purified plasma RS. RS in plasma and amniotic fluid were similar in molecular weight, isoelectric point and immunological properties. Immunoreactivity of radio-iodinated amniotic fluid RS was lower than that of plasma RS. Measured by direct radioimmunoassay, RS-levels were only 10–22% of those obtained with indirect assay in 22 amniotic fluid samples. This difference suggests that amniotic fluid RS is less immunoreactive than plasma RS, possibly due to biochemical alteration or complex formation. No such difference in immunoreactivity was noticed in RS of decidual and placental cytosolic fraction. |
| Keywords: | Amniotic fluid Angiotensinogen Decidua Placenta Renin substrate |
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