| 自噬与炎性反应之间分子联系的研究进展 |
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| 引用本文： | 徐倩,哈小琴. 自噬与炎性反应之间分子联系的研究进展[J]. 基础医学与临床, 2017, 37(11). DOI: 10.3969/j.issn.1001-6325.2017.11.029 |
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| 作者姓名： | 徐倩 哈小琴 |
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| 作者单位： | 1. 兰州军区兰州总医院检验科,甘肃兰州730050;兰州大学第二医院,甘肃兰州730030;甘肃省干细胞与基因药物重点实验室, 甘肃兰州730050;2. 兰州军区兰州总医院检验科,甘肃兰州,730050 |
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| 基金项目： | 甘肃省科技厅杰出青年科技基金 |
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| 摘 要： | 自噬是机体重要的代谢过程,参与细胞的多种应激反应如炎性反应。自噬与炎性反应之间具有密切的分子联系。一方面,多种炎性反应介质可调控自噬发生及自噬基因的转录;另一方面,自噬通过多种方式可抑制机体过激的炎性反应。因此,机体的多种炎性反应疾病包括克罗恩病(CD)可能与自噬缺陷相关。
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| 关 键 词： | 自噬 炎性反应 克罗恩疾病 |
Research progress in molecular connection between autophagy and inflammation |
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| XU Qian,HA Xiao-qin. Research progress in molecular connection between autophagy and inflammation[J]. Basic Medical Sciences and Clinics, 2017, 37(11). DOI: 10.3969/j.issn.1001-6325.2017.11.029 |
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| Authors: | XU Qian HA Xiao-qin |
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| Abstract: | Autophagy is an important metabolic mechanism involved in stress responses of cells such as inflamma -tion.A close molecular connection between autophagy and inflammation .On the other side , some inflammatory me-diators can regulate autophagy and its translation;Autophagy is able to suppress the excessive inflammation through various pathway .Therefore , deficient autophagy may associate with inflammatory diseases such as Crohn 's disease ( CD) . |
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| Keywords: | autophagy inflammation Crohn's disease |
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