Differential neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in Swiss-Webster mice from different sources |
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| Authors: | R E Heikkila |
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| Affiliation: | 1. Duke Clinical Research Institute and Division of Cardiology, Durham, NC;2. Division of Cardiology, Duke University Medical Center, Durham, NC;3. Heart and Vascular Institute, Anchorage, AL;4. Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN;5. Division of Research, Kaiser Permanente Northern California, Oakland, CA;6. Division of Cardiology, Massachusetts General Hospital, Boston, MA;1. CNR Institute of Clinical Physiology, ASST- Great Metropolitan Hospital Niguarda, Milan, Italy;2. Epilepsy Surgery Centre, Centre of Sleep Medicine, ASST- Great Metropolitan Hospital Niguarda, Milan, Italy;3. Neurology and Stoke Unit, Department of Neuroscience, ASST-Great Metropolitan Hospital Niguarda, Milan, Italy;4. Spinal Unit, ASST- Great Metropolitan Hospital Niguarda, Milan, Italy |
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| Abstract: | Male Swiss-Webster mice obtained from three different commercial suppliers were treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Mice from one of the three suppliers were considerably more sensitive to the neurotoxic effects of MPTP than mice from the others. For example the MPTP-induced decrements in the neostriatal levels of dopamine and its metabolites, which are a reflection of the neurotoxic process, were considerably greater in the sensitive strain than in the less sensitive strains. |
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