An advanced mouse model for human skin wound healing |
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| Authors: | Jie Wen Xiangyong Li Xue Leng Xin Xu Xunwei Wu |
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| Affiliation: | 1. Laboratory for Tissue Engineering and Regeneration, School of Stomatology, Shandong University, Jinan, Shandong, China;2. College of Life Science, Dezhou University, Dezhou, Shandong, China |
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| Abstract: | Here, we report a model for studying wound repair based on skin regenerated from human tissue culture‐expanded cells. The reconstituted skin (hRSK) responds to injury similar to that of intact human skin, and its constituent cells contribute to the healing process. As we have demonstrated that hRSK composed of GFP‐labelled cells also heals “normally,” we believe this model will be useful in analysing the wound repair process using genetically modified human cells. |
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| Keywords: | cultured cells human reconstituted skin mouse model regeneration wound healing |
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