UVA‐1 exposure in vivo leads to an IL‐6 surge within the skin |
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| Authors: | Lars Alexander Schneider Katharina Raizner Meinhard Wlaschek Peter Brenneisen Kerstin Gethöffer Karin Scharffetter‐Kochanek |
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| Institution: | 1. University Department of Dermatology and Allergology, Ulm, Germany;2. Department of Dermatology and Allergology, Helios Klinik Rottweil, Rottweil, Germany;3. Heinrich‐Heine‐University Medical Faculty Biochemistry & Molecular Biology I, Duesseldorf, Germany |
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| Abstract: | UVA‐1 is a known promotor of skin ageing. Cytokines like IL‐1α, Il‐1β or TNF‐α, VEGF and IL‐6 orchestrate UV effects, and IL‐6 is furthermore an effector of UVA‐induced photoageing. We investigated how fractionated UVA‐1 doses influence the cytokine milieu and especially the IL‐6 levels in the skin in vivo. In a study with 35 participants, we exposed previously unirradiated human skin to three UVA‐1 irradiation regimes. Cytokine levels in interstitial skin fluid were measured up to 48 hours postexposure and compared to unirradiated control skin fluid. Our results show that IL‐6 levels increased significantly after UVA‐1 exposure at selected time points. The other candidates IL‐1α, Il‐1β or TNF‐α and VEGF show no significant response after UVA‐1 exposure in vivo. UVA‐1 thus raises selectively IL‐6 levels in vivo, a fact that underlines its role in photoageing and has potential implications for its modulatory effect on photoageing pathology. |
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| Keywords: | IL‐6 inflammation skin suction blister UVA radiation UVA‐1 |
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