以CT图像为基础构建人狭窄颈动脉的血流动力学模型

目的探索以CT图像为基础构建动脉血流动力学模型的技术方法,对颈动脉狭窄局部进行计算血流动力学（computationalfluid dynamics,CFD）数值模拟。方法以CT图像为基础进行颈动脉三维几何建模,依据MRI测量的模型出入口血流速度确定数值模拟的边界条件。结果数值模拟结果包括狭窄颈动脉内的速度场和壁面剪应力（wall shear stress,WSS）分布,可见狭窄段血管WSS增高,且在狭窄邻近区域出现新的血液逆流区（对应低或振荡的WSS）。结论以CT图像为基础的CFD技术是在体评价人狭窄颈动脉内血流动力学状况与颈动脉斑块之间关系的有效方法。

CT image-based computational fluid dynamics modeling of human stenosed carotid artery

Objective To investigate the feasibility of using CT image-based computational fluid dynamics(CFD) to simulate numerically the local hemodynamics in anatomically realistic human stenosed carotid bifurcations. Methods The three-dimensional(3D) geometric models were reconstructed from CT imaging. Velocities derived from 3D phase-contrast(PC) MRI measurements were used as boundary conditions for CFD calculation. Results Maps of wall shear stress(WSS) distributions and vectors of velocity in the flow field were presented. The geometrical alterations caused by the plaques can give rise to a series of hemodynamic changes, such as rise in WSS within stenoses and regions of slow, reversed flow(hence low, oscillatory WSS) near the plaques. Conclusion CT image-based CFD is a reliable approach for elucidating the role of local hemodynamics in the progression of carotid plaques and the potentially catastrophic events in the end stages of the disease.