我院2001～2006年抗癫痫药血药浓度监测数据分析

目的:阐述治疗药物监测(TDM)对抗癫痫药合理应用的意义,关注临床科室对TDM的认识程度。方法:建立抗癫痫药Access数据库,对我院2001～2006年抗癫痫药TDM结果进行分析。结果:我院抗癫痫药监测例数逐年上升;由监测结果计算的抗癫痫药有效浓度、高血药浓度、低血药浓度比例显示血药浓度监测极有必要,但患者的个体用药信息缺乏限制了抗癫痫药个体化用药的发展。结论:TDM虽应用日益广泛,但仍需医师、药师共同努力,以最大限度地保证抗癫痫药的个体化应用。

Blood Concentration Monitoring of Anti- epileptic Drugs in Our Hospital from 2001 to 2006: Analysis of Monitoring Data

OBJECTIVE： To discuss the significance of therapeutic drug monitoring （TDM） for rational administration of anti-epileptic drugs and to probe into the cognition of clinic staff on TDM. METHODS： Access database of antiepileptic drugs was established to analyze the TDM data of antiepileptic drugs used from 2001 to 2006. RESULTS： The TDM cases of antiepileptic drugs increased year by year. The proportions of effective concentration, high blood drug concentration and low blood drug concentration derived from TDM data showed that it is quite necessary to conduct blood drug concentration monitoring. But the lack of individual medication information has hindered the development of patients＇ individualized medication of antiepileptic drugs. CONCLUSION： The application of TDM is increasingly widespread; however, the joint efforts of physicians and pharmacists are still needed to ensure individualized medication of anti - epileptic drugs.