益气活血药对脑缺血再灌注模型脑水肿及超微结构的影响

为探讨益气活血方药治疗缺血性中风的药理机制，根据益气活血法选用北芪、益母草、毛冬青等组成益气活血口服液，观察其对大鼠缺血善灌注大脑中动脉闭塞（MCAO）模型的脑水肿及超微结构、神经病学评分的影响。结果：益气活血口服液能不同程度降低缺血后脑组织含水量，减轻脑缺血再灌注早期所致的神经损伤症状，减轻脑组织超微结构的损害。提示：益气活血药可通过保护血管内皮细胞功能、基膜的完整性，改善微循环，从而减轻脏水肿程度，并对迟发性神经元坏死有保护作用；也为益气活血口服液的临床应用提供了实验依据。

Effects of Qi Reinforcing and Blood-Circulation Activating Medicines on Cerebral Edema and Brain Ultrastructure of Cerebral Ischemic Rat Model After Reperfusion

Yiqi Huoxue Oral Liquid(YHOL) was a formula with Qi Reinforcing and bind-circulationactivating actions consisting of Radix Astragali seu Hedysari,Heada,Radix Ilicis Pubesceatis,etc,To study its Pharmacological mechanism, the effects of YHOL on cerebral edema and ultra- struture of cereblal ischemic rat model after reperfusion were observed. The results showed that YHOLdecreased the water content of ischemic barn to some extent, alleviated the neurological symptoms andreduced the damage of brain ultrastructure in the early stage of reperfusion. It is indicated that YHOLcan reduce cereblal edema by protecting the fumction of vascular endothelial cell and the integrity of basicmembranes and improving microcirculation, and exerts a protective effect on the delayed death of neuron.This will Provide an experimental evidence for the clinical application of YHOL.