| 肿瘤转移抑制基因nm23-H1蛋白在肺癌中的表达 |
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| 引用本文： | 张良,万豫尧,朱明,张尚福,成娘.肿瘤转移抑制基因nm23-H1蛋白在肺癌中的表达[J].广州中医药大学学报,1999,16(1):69-71. |
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| 作者姓名： | 张良 万豫尧 朱明 张尚福 成娘 |
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| 作者单位： | 1. 广州中医药大学第二附属医院外科,广州510120
2. 华西医科大学第一附属医院病理科,成都610041 |
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| 摘 要： | 为了解ｎｍ２３－Ｈ１基因在肺癌中的表达及与肺癌淋巴转移的关系，探讨其对肺癌淋巴结转移的抑制作用，对７８例肺癌存档石蜡块进行重新切片，采用ｎｍ２３－Ｈ１单克隆抗体进行免疫组化染色（ＳＰ法）。结果：ｎｍ２３－Ｈ１蛋白表达与肺癌组织类型和淋巴结转移无关（Ｐ＞０．０５），而与肺癌细胞分化及发生有关（Ｐ＜０．０１）。结果提示ｎｍ２３－Ｈ１基因对肺癌的形成有重要作用，在肺癌中ｎｍ２３－Ｈ１基因不具有肿瘤转移抑制功能。
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| 关 键 词： | 肺肿瘤/病理学 @基因 nm23-H1 基因 抑制 肿瘤 肿瘤转移 淋巴转移 |
Expression of Tumor Metastasis-Suppressor Gene nm23-H1 Protein in Lung Carcinoma |
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| ZHANG Liang,WAN Yu-yao,ZHU Ming,ZHANG Shang-fu,CHENG Liang.Expression of Tumor Metastasis-Suppressor Gene nm23-H1 Protein in Lung Carcinoma[J].Journal of Guangzhou University of Traditional Chinese Medicine,1999,16(1):69-71. |
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| Authors: | ZHANG Liang WAN Yu-yao ZHU Ming ZHANG Shang-fu CHENG Liang |
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| Abstract: | To study the relationship between expression of gene nm23-H 1 protein and lymph node metastasis in lung carcinoma, 78 paraffin-embedded specimens of lung cancer were tested by immunohistochemical technology. The results showed that expression of gene nm23-H 1 protein was not related to histological types of lung carcinoma and lymph node metastasis (P> 0.05 ),but related to the formation of lung carcinoma and its tumor differentiation (P< 0.01 ).It is concluded that gene nm23-H 1 plays an important role in tumorigenesis and exerts no inhibitory effect on the metastasis of lung carcinoma. |
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| Keywords: | LUNG NEOPLASMS/pathology @GENE nm23-H 1 GENES SUPPRESSOR TUMOR NEOPLASM METASTASIS LYMPHATIC METASTASIS |
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