| 睫状节神经营养因子在大鼠损伤坐骨神经中的表达变化 |
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| 引用本文： | 崔学芝,邱一华.睫状节神经营养因子在大鼠损伤坐骨神经中的表达变化[J].南通医学院学报,2000,20(3):223-224. |
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| 作者姓名： | 崔学芝 邱一华 |
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| 作者单位： | 南通医学院神经科学研究所 |
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| 基金项目： | 国家杰出青年科学基金!资助 ( 3 942 5 0 0 6)，江苏省教委青蓝工程资助 |
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| 摘 要： | 目的：探索坐骨神经损伤后睫状节神经营养因子ＣＮＴＦ的表达变化。方法：采用抗ＣＮＴＦ抗体以Ｗｅｓｔｅｒｎ Ｂｌｏｔ方法检测大鼠损伤两周坐骨神经远侧端和正常神经中ＣＮＴＦ表达。结果：正常神经组织中在２２ｋＤ处有特异性ＣＮＴＦ阳性反应条带，在损伤两周的坐骨神经远侧端中尚未出现ＣＮＴＦ阳性反应条带。结论：正常成年鼠坐骨神经中ＣＮＴＦ表达处于一定的水平。神经损伤两周后的坐骨神经远侧端中ＣＮＴＦ表达明显减少。
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| 关 键 词： | 睫状神经营养因子 坐骨神经损伤 蛋白表达 |
THE CHANGES ABOUT THE EXPRESSION OF CILIARY NEUROTROPHIC FACTOR IN INJURED SCIATIC NERVE OF RAT |
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| CUI Xue-zhi,QIU Yi-hua,HUANG Hui-wei,et al.THE CHANGES ABOUT THE EXPRESSION OF CILIARY NEUROTROPHIC FACTOR IN INJURED SCIATIC NERVE OF RAT[J].ACTA Academiae Medicinae Nantong,2000,20(3):223-224. |
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| Authors: | CUI Xue-zhi QIU Yi-hua HUANG Hui-wei |
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| Abstract: | Objective: To probe CNTF changes in injuried sciatic nerve for 2wk.Methods: By anti-CNTF antibody, Western Blot was used to exam the different expression of CNTF in the distal stump of transected sciatic nerve for 2wk and normal sciatic nerve.Results: Special positive band was found around 22kD in normal nerve , no band in the distal stump of the injuried sciatic nerve. Conclusion:The expression of CNTF was in normal level in the normal sciatic nerve and decreased significantly in the distal stump of injuried nerve. |
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| Keywords: | Ciliary Neurotrophic Factor(CNTF) Injuried sciatic nerve Protein expression rat |
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