放射治疗对恶性肿瘤患者T细胞亚群影响的研究

目的：探讨放射治疗对细胞免疫功能的影响以及免疫治疗在放疗过程中的作用。方法：将６６例恶性肿瘤患者分为单纯放疗组和放疗＋免疫增强剂治疗组，采用直线加速器高能Ｘ线和电子线局部外照射，观察放疗前后两组患者Ｔ细胞亚群水平。结果：单纯放疗组后ＣＤ３、ＣＤ４、ＣＤ８与疗前比均明显降低（Ｐ〈０．０５）。放疗＋免疫增强剂治疗组放疗前后对比，ＣＤ３、ＣＤ４、ＣＤ８水平无差异（Ｐ〉０．０５）。结论：肿瘤患者存在细胞免

STUDY ON THE EFFECTS OF RADIOTHERAPY ON T-CELL SUBGROUPS OF THE MALIGNANT TUMOR PATIENTS

Objective:To study on whether radiotherapy affects on T cell subgroups,and to research on the effects of immunoenhancing agents on the immune side effects of radiotherapy.Methods:Sixty-six malignant tumour patients were divided into two groups,radiotherapy alone and radiotherpay plus immunoinhancing agents therapy groups.All patients were subjected to high energy X-rays and electronic rays outer local reginal therapy.T cell subgroups levels were measured before and after the radiotherapy.Results:CD 3,CD 4 and CD 8 decreased significantly after radiotherapy (P<0.05) in radiotherapy alone group.There were no differences in CD 3,CD 4 and CD 8 before and after radiotherapy in the group of radiotherapy plus immunoinhancing agents therapy.Conclusions:Radiotherapy may cause the decrease in T cells of all subgroups and immunoinhancing agents may antagonize the side effects of radiotherapy.