p16抑癌基因在卵巢浆液性肿瘤中的表达及意义

目的：研究ｐ１６在卵巢浆液性肿瘤中的表达，并探讨其表达与肿瘤的性质、临床分期、组织分化及腹水的关系。方法：用Ｓ－Ｐ免疫组化法，检测了８１例卵巢浆液性肿瘤中抑癌基因ｐ１６的表达。结果：ｐ１６在恶性、交界性及良性肿瘤中的阳性表达率分别为２０．７％、６０．０％和６９．２％。交界性和良性肿瘤的表达率皆明显高于恶性肿瘤（Ｐ〈０．０５，Ｐ〈０．０１）。ｐ１６的表达与卵巢癌的组织分化和临床有关（Ｐ〈０．０１，Ｐ

EXPRESSION AND SIGNIFICANCE OF TUMOR SUPPRESSOR GENE p16 IN OVARIAN SEROUS TUMORS

Objective: To investigate the expression of the tumor suppressor gene p16 in ovarian serous tumors and its relationship with clinicopathological features. Method: Using S-P immunohistochemical analysis ,we investigated the expression of p16 in 81 cases of ovarian serous neoplasms.Results:The positive rate of p16 expression in malignant,borderline and benign tumors was 20.7%,60.0% and 69.2%, the rates of p16 expression in benign and borderline tumors were respectively higher than that in malignant tumors(P<0.05,P<0.01).Good correlations of p16 expression were noted with pathological grades and clinical cancer stages(P<0.01,P<0.01).Statistical analysis did not show observable difference between p16 expression and lymph node metastasis as well as ascites.Conclusion: The results suggest that p16 is well related with the occurrence and department of ovarian cancer.