| 抗肿瘤药治疗新靶点——Na~+-H~+交换器及其抑制剂研究进展 |
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| 引用本文： | 王卓,徐云根,郭青龙,王秋娟.抗肿瘤药治疗新靶点——Na~+-H~+交换器及其抑制剂研究进展[J].药学进展,2010,34(2). |
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| 作者姓名： | 王卓 徐云根 郭青龙 王秋娟 |
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| 作者单位： | 1. 中国药科大学生理学教研室,江苏,南京,210009;中国药科大学江苏省肿瘤发生与干预重点实验室,江苏,南京,210009
2. 中国药科大学江苏省肿瘤发生与干预重点实验室,江苏,南京,210009 |
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| 基金项目： | 国家自然科学基金资助项目，江苏省自然科学基金资助项目 |
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| 摘 要： | Na+-H+交换器是一类普遍存在于真核细胞膜上的离子交换蛋白,可介导胞外钠离子和胞内氢离子的交换,与肿瘤生长、代谢、血管新生以及多药耐药等密切相关,故有望成为抗肿瘤药物开发的新靶点.介绍了Na+ -H+交换器基本原理及其抑制剂研究进展,旨在为抗肿瘤新药的开发拓宽思路并提供参考.
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| 关 键 词： | Na+-H+交换器 肿瘤发生 肿瘤转移 肿瘤血管生成 多药耐药 |
Advances in Research on Na~+-H~+ Exchanger,a Novel Target for Anticancer Drugs,and Its Inhibitors |
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| WANG Zhuo,XU Yun-gen,GUO Qing-long,WANG Qiu-juan.Advances in Research on Na~+-H~+ Exchanger,a Novel Target for Anticancer Drugs,and Its Inhibitors[J].Progress in Pharmaceutical Sciences,2010,34(2). |
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| Authors: | WANG Zhuo XU Yun-gen GUO Qing-long WANG Qiu-juan |
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| Institution: | WANG Zhuo1,2,XU Yun-gen2,GUO Qing-long1,WANG Qiu-juan1,2(1.Department of Physiology,China Pharmaceutical University,Nanjing 210009,China,Jiangsu Key Laboratory of Carcinogenesis , Intervention,China) |
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| Abstract: | The Na~+-H~+ exchanger(NHE) family is a class of proteins which exist widely on the membrane of eukaryotic cells and mediate the exchange of extracellular Na+ and intracellular H+.It is reported to be highly involved in tumor growth,cell metabolism,angiogenesis and multidrug resistance.Consequently,NHE may be a new target for the anti-tumor drugs.The recent advances in the research on the basic theory of NHE and the related inhibitors in development were reviewed,so as to widen the thought of research and p... |
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| Keywords: | Na~+-H~+ exchanger carcinogenesis tumor metastasis tumor angiogenesis multidrugresistance |
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