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| 前列地尔注射液治疗下肢动脉硬化闭塞症的临床研究 | |
| 引用本文： | 黄晓钟,张纪蔚,郭大乔,李建新,陈忠,金毕,郑起,黄建华,韩萍.前列地尔注射液治疗下肢动脉硬化闭塞症的临床研究[J].上海医药,2011,32(12):598-600. |
| 作者姓名： | 黄晓钟 张纪蔚 郭大乔 李建新 陈忠 金毕 郑起 黄建华 韩萍 |
| 作者单位： | 1. 上海交通大学医学院附属仁济医院血管外科,上海,200001 2. 上海复旦大学医学院附属中山医院血管外科,上海,200032 3. 首都医科大学附属宣武医院血管外科,北京,100053 4. 首都医科大学附属北京安贞医院血管外科,北京,100029 5. 华中科技大学同济医学院附属协和医院血管外科,武汉,430074 6. 上海市第六人民医院普外科,上海,200233 7. 中南大学附属湘雅医院普外科,长沙,410008 8. 中国医科大学附属盛京医院普外科,沈阳,110004 |
| 摘 要： | 目的：以前列地尔注射液（商品名：凯时,北京泰德制药有限公司生产）为阳性对照药物,评价上海福达制药有限公司生产的前列地尔注射液治疗下肢动脉硬化闭塞症的疗效与安全性。方法：全国8家医院采用随机、双盲、阳性药平行对照研究,观察试验组（前列地尔,114例）、对照组（凯时,110例）在综合疗效、间歇性跛行、静息痛、踝肱指数值的改善以及不良事件发生情况。结果：试验组总有效率为87.50%,对照组为85.45%。两组不良事件的发生率、严重程度以及与药物的相关性之间的比较,差异均无统计学意义（P〉0.05）。结论：前列地尔与凯时治疗下肢动脉硬化症的有效性与安全性无差异。 |
| 关 键 词： | 前列腺素El 下肢动脉硬化闭塞症 药物治疗 |
Clinical study on alprostadil injection for limb arterial stenosis |
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| HUANG Xiao-zhong,ZHANG Ji-wei,GUO Da-qiao,LI Jian-xin,CHEN Zhong,JIN Bi,ZHENG Qi,HUANG Jian-hua,HAN Ping.Clinical study on alprostadil injection for limb arterial stenosis[J].Shanghai Medical & Pharmaceutical Journal,2011,32(12):598-600. | |
| Authors: | HUANG Xiao-zhong ZHANG Ji-wei GUO Da-qiao LI Jian-xin CHEN Zhong JIN Bi ZHENG Qi HUANG Jian-hua HAN Ping |
| Institution: | HUANG Xiao-zhong 1,ZHANG Ji-wei 1,GUO Da-qiao 2,LI Jian-xin 3,CHEN Zhong 4,JIN Bi 5,ZHENG Qi 6,HUANG Jian-hua 7,HAN Ping 8(1.Department of Vascular Surgery,Renji Hospital of Shanghai affiliated to School of Medicine,Shanghai Jiao Tong University,Shanghai,200001,2.Department of Vascular Surgery,Zhongshan Hospital of Shanghai affiliated to School of Medicine,Fudan University,200032,3.Department of Vascular Surgery,Xuanwu Hospital of Beijing affiliated to the Capital Medical University,Beijing,100053,... |
| Abstract: | Objective:To determine the efficacy and safety of prostaglandin E1,Liple injection for treatment of patients with arteriosclerosis obliterans(ASO).Methods:The results of treatment were evaluated by comparison of Liple with another similar productKaishi.A randomized,double-blind,positive-controlled parallel control study was designed to treat patients with ASO in 8 hospitals and patients were divided two groups,one for observation with 114 patients and the other for control with 110 patients.The comprehensiv... |
| Keywords: | prostaglandin El arteriosclerosis obliterans drug treatment |
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