| 泛素-蛋白酶体系统在心肌梗死中的病理生理意义 |
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| 引用本文： | 张赟,戴翠莲. 泛素-蛋白酶体系统在心肌梗死中的病理生理意义[J]. 中国病理生理杂志, 2010, 26(6): 1234-1236. DOI: 10.3969/j.issn.1000-4718.2010.06.038 |
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| 作者姓名： | 张赟 戴翠莲 |
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| 作者单位： | 遵义医学院附属医院心内科, 贵州 遵义 563003 |
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| 摘 要： | 心肌梗死后心室重塑是慢性心力衰竭的主要原因.因凋亡和坏死而导致的心肌细胞死亡可造成心肌重塑,病理性心肌肥大和左心室扩张是其主要特征.研究表明,泛素蛋白酶体系统(ubiquitin proteasome system,UPS)可能参与这一过程.
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| 关 键 词： | 泛素-蛋白酶体系统 心脏 心肌梗死 |
| 收稿时间： | 2009-04-14 |
Pathophysiological significance of ubiquition-proteasome system in myocardial infarction |
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| ZHANG Yun,DAI Cui-lian. Pathophysiological significance of ubiquition-proteasome system in myocardial infarction[J]. Chinese Journal of Pathophysiology, 2010, 26(6): 1234-1236. DOI: 10.3969/j.issn.1000-4718.2010.06.038 |
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| Authors: | ZHANG Yun DAI Cui-lian |
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| Affiliation: | Department of Cardiology, The Affiliated Hospital of Zunyi Medical College, Zunyi 563003, China.
E-mail: dai_cui_lian@yahoo.com.cn |
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| Abstract: | Degradation of most proteins in eukaryotic cells is through the ubiquition-proteasome system (UPS). Recently, it demonstrated that UPS regulates cell apoptosis and cardiac hypertrophy. The differences of UPS regulation lie in E3 ligases, which specifically recognize targets and direct the ubiquitination process. Recent evidence suggests that atrogin-1/muscle atrophy F-box (Mafbx) and muscle RING finger 1 (MuRF1) may be critical mediators of the heart and muscle atrophy and hypertrophy. This review summarizes the possible relationship between UPS and cardiac dysfunction after myocardial infarction in order to inhibit cardiac dysfunction after myocardial infarction. |
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| Keywords: | Ubiquitin proteasome system Heart Myocardial infarction |
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