二甲亚砜对庆大霉素耳蜗毒性的影响

豚鼠４５只，随机分为３组，第１组为正常对照组，第２组为肌注庆大霉素组（ＧＭ组）， 第 ３组在肌注 ＧＭ的同时，腹腔注射二甲亚砜（ＧＭ＋ＤＭＳＯ组），以探讨 ＤＭＳＯ对 ＧＭ耳毒性的 预防作用。结果表明；ＧＭ＋ＤＭＳＯ组动物耳蜗神经动作电位（ＡＰ）阈值较ＧＭ组明显为低，ＡＰ （Ｎ１）潜伏期ＧＭ组较ＧＭ＋ＤＭＳＯ组显著延长；耳蜗铺片显示。ＧＭ＋ＤＭＳＯ组外毛细胞受损程度 较ＧＭ组明显为轻。提示ＤＭＳＯ可有效地减轻ＧＭ的耳蜗毒性。

Effects of dimethyl sulfoxide on gentamycin ototoxicity

Forty five guinea pigs were divided at random into three groups;the first one was the normal group; the second was the gentamycin group; the third was the gentanmycin plus dimethyl sulfoxide group(GM+DMSO group). The electrochleographic and light microscopic techniques were used to study the effects of DMSO on gentamycin ototoxicity. The results showed that the hearing threshold of AP (action potential) was significantly (P<0.01) higher in the GM (gentamycin) group than that in the GM plus DMSO(dimethyl sulfoxide) group and the latency of N1 was significantly (P<0. 01) longer in GM group than that in GM plus DMSO group. The structural damage of outer hair cells was severer in the GM group than that in the GM plus DMSO group. It demonstrated the good efficiency of DMSO against GM ototoxicity.