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Establishment of a Human Small Cell Lung Cancer Cell Line Producing a Large Amount of Anti-diuretic Hormone |
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| Authors: | Takeo Terasaki Yoshihiro Matsuno Yukio Shimosato Ken Yamaguchi Hiroshi Ichinose Toshiharu Nagatsu Kanefusa Kato |
| Affiliation: | Pathology Division, National Cancer Center Research Institute 1-1 Tsukiji 5-chome, Chuo-ku, Tokyo 104;Growth Factor Division, National Cancer Center Research Institute, 1-1 Tsukiji 5-chome, Chuo-ku, Tokyo 104;Clinical Laboratory Division, National Cancer Center Hospital, 1-1 Tsukiji 5-chome, Chuo-ku, Tokyo 104;Division of Molecular Genetics (II), Institute for Comprehensive Medical Science, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake 470-11;Department of Biochemistry, Institute for Developmental Research, Aichi Prefectural Colony, 713-8 Kamiya-cho, Kasugai 480-03 |
| Abstract: | A new cancer cell line (Lu-165) producing a large amount of anti-diuretic hormone (ADH, 2.8 μg/g protein) was established from a 50-year-old small cell lung cancer patient presenting with a syndrome of inappropriate anti-diuretic hormone secretion. These cells grew well in serum-supplemented medium and during more than 100 passages they continued producing a large amount of this hormone. This cell line will be a useful tool for studies of the biochemistry and pathology of ADH-producing cancer. |
| Keywords: | Anti-diuretic hormone Small cell lung cancer Cell line |