广西壮族系统性红斑狼疮与HLA-DRB1等位基因相关性研究

目的 探讨广西壮族系统性红斑狼疮(SLE)与HLA-DRB1基因的相关性。方法 用聚合酶链反应-序列特异性引物(PCR-SSP)方法,对52例SLE壮族患者和70例壮族健康人的HLA-DRB1基因进行研究。结果 SLE患者HLA-DRB1*1401及DRB1*16两个等位基因的频率低于正常对照组(RR=0.28,χ²=5.00,P=0.02及RR=0.39,χ²=3.95,P=0.05),患者组和对照组均未检出HLA-DRB1*08、DRB1*11和DRB1*13等位基因。结论 提示HLA-DRB1*1401及DRB1*16等位基因可能是广西壮族人SLE的保护基因,未发现易感基因。

Association of HLA-DRB1 Alleles and Systematic Lupus Erythematosus of the Zhuang Nationality in Guangxi Province

Objective To study the relationship between HLA-DRB1 alleles and the systematic lupus erythematosus of the Zhuang Nationality in Guangxi Province.Methods Allele polymerase chain reaction-sequence specific primers(PCR-SSP)were used to study the HLA-DRB1 allele genes in 52 patients with SLE and 70 healthy controls of the Zhuang Nationality in Guangxi Province.Results The allele frequencies of HLA-DRB1*1401 and HLA-DRB1*16 were significantly less in SLE patients than those of the controls(RR=0.28,χ²=5.00,P=0.02 and RR=0.39,χ²=3.95,P=0.05).HLA-DRB1*08,DRB1*11 and DRB1*13 alleles were not found in these two groups.Conclusion Our data suggest that the HLA-DRB1*1401 and HLA-DRB1*16 might be protecting genes for SLE in Guangxi Zhuang nationality.No susceptible gene is found in our study.