| 微管相关蛋白2在难治性癫痫患者颞叶中的表达 |
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| 引用本文： | 郭珍立,柯贤军,王学峰,席志芹,龚云,李劲梅,刘凤英,孙纪军,吴原. 微管相关蛋白2在难治性癫痫患者颞叶中的表达[J]. 中国临床神经科学, 2006, 14(4): 368-372 |
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| 作者姓名： | 郭珍立 柯贤军 王学峰 席志芹 龚云 李劲梅 刘凤英 孙纪军 吴原 |
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| 作者单位： | 1. 湖北省新华医院,湖北省脑科中心神经内科,430015
2. 重庆医科大学附属第一医院神经内科,重庆市神经病学重点实验室,400016 |
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| 摘 要： | 目的:研究微管相关蛋白2(MAP2)在难治性癫患者颞叶中的表达,探索其在难治性癫中的作用。方法:收集难治性癫患者术后脑组织,用免疫组化法从蛋白水平测定MAP2在难治性癫患者脑组织中的表达,并与对照组进行比较。结果:免疫组化检测发现目的蛋白MAP2比对照组明显增加(t=5.338,P<0.05),这种蛋白主要分布在神经元的树突和轴突。结论:MAP2在难治性癫患者脑组织表达增强,提示他们可能参与了难治性癫的形成。
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| 关 键 词： | 癫 微管相关蛋白2 免疫组织化学 |
| 文章编号： | 1008-0678(2006)04-0368-05 |
| 修稿时间： | 2006-01-10 |
Upregulated Expression of Microtubule-associated Protein 2 in the Temporal Lobe of Patients with Intractable Epilepsy |
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| GUO Zheng-Li,KE Xian-Jun,WANG Xue-Feng,XI Zhi-Qin,GONG Yun,LI Jing-Mei,LIU Feng-Ying,SUN Ji-Jun,WU Yuan. Upregulated Expression of Microtubule-associated Protein 2 in the Temporal Lobe of Patients with Intractable Epilepsy[J]. Chinese Journal of Clinical Neurosciences, 2006, 14(4): 368-372 |
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| Authors: | GUO Zheng-Li KE Xian-Jun WANG Xue-Feng XI Zhi-Qin GONG Yun LI Jing-Mei LIU Feng-Ying SUN Ji-Jun WU Yuan |
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| Abstract: | Aim: To investigate the expression of microtubule-associated protein 2 (MAP2) in the temporal lobes of the patients with intractable epilepsy(IE). Methods: MAP2 protein expression in brain tissue of IE patients and Nonepileptogenic control was studied by using immunohistochemistry. Results: The immunohistochemistry data showed that the expression of MAP2 in epilepsy patients was significantly higher than those in the control group (t = 5.338,P <0.05), and the protein was mainly expressed in the axon and dendrite of the neuron. Conclusion: The study shows that upregulation of MAP2 is seen in the patients with IE. It is suggested that MAP2 might be involed in IE pathogeneticsis. |
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| Keywords: | epilepsy microtubule-associated protein 2 immunohistochemistry |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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