Effects of theophylline,terbutaline, and prednisone on antigen-induced bronchospasm and mediator release |
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Authors: | George L Martin Paul C Atkins Eliot H Dunsky Burton Zweiman |
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Institution: | From University of Pennsylvania School of Medicine, Department of Medicine, Allergy and Immunology Section Philadelphia, Pa., U.S.A. |
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Abstract: | Eleven subjects demonstrating clinical, skin, and inhalation sensitivity to grass or ragweed pollen underwent serial inhalation challenges, with and without orally administered theophylline, terbutaline, and prednisone. Comparisons of antigen sensitivity and mediator release were made during these challenges. All three drugs significantly reduced antigen sensitivity (PD20 inhalation units increasing from 670 to ≧ 3,280). Peak plasma histamine levels after antigen challenge decreased from 11.4 ng/ml to ≦ 3.4 ng/ml during all drug administrations. Similarly, the percent increase in serum neutrophil chemotactic activity (NCA) also decreased, from 96% to ≦ 36% during drug administrations. However, even at antigen doses resulting in bronchospasm during drug administration the systemic appearance of NCA and histamine were reduced. We conclude that prednisone, theophylline, and terbutaline significantly reduce antigen-induced bronchospasm and mediator release. The occurrence of bronchospasm despite the inhibition of histamine and NCA suggests either that the local concentration of these mediators are critical or that other mediators produce the bronchospasm observed. |
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Keywords: | Reprint requests to: Paul C Atkins M D University of Pennsylvania School of Medicine 520 Johnson Pavilion 36th and Hamilton Walk Philadelphia PA 19104 |
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