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MSH and MIF-I in animal models of tardive dyskinesia |
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| Authors: | Kenneth L. Davis Abba J. Kastin Barbara A. Beilstein Adela L. Vento |
| Affiliation: | 1. Department of Psychiatry of the Bronx Veterans Administration Medical Center and Mount Sinai School of Medicine, New York, NY 10468, USA;2. Endocrinology Section of the Medical Service of the Veterans Administration Medical Center and Tulane University School of Medicine, New Orleans, LA 70146, USA;3. Psychiatric Clinical Research Center of the Veterans Administration Medical Center and Stanford University School of Medicine, Palo Alto, CA 94304, USA |
| Abstract: | α-Melanocyte stimulating hormone (MSH) and MSH release inhibiting factor (MIF-I) were tested for their effects on animals with prior exposure to haloperidol. Such animals are known to have an augmented stereotypic response to dopamine agonist and have been used as an animal model of tardive dyskinesia. Both MSH and MIF-I increased the stereotypy that followed the administration of the lowest dose of apomorphine (0.125 mg/kg), suggesting that MSH and MIF-I might weakly increase dopaminergic transmission. |
| Keywords: | α-melanocyte-stimulating hormone (MSH) MSH release inhibiting factor (MIF) Tardive dyskinesia Apomorphine Autoreceptor |
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