Schedule-induced ethanol polydipsia: Function of ethanol concentration |
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Authors: | Timothy A Roehrs Herman H Samson |
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Institution: | Alcoholism and Drug Abuse Institute and Department of Psychology, University of Washington, Seattle, WA 98195, USA |
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Abstract: | Rats were maintained in cages with automatic food dispensers that provided a 24 hr feeding regimen known to produce schedule-induced ethanol polydipsia. For ten days water was the only available fluid; then for 17 days either 5% or 10% ethanol replaced water. The ethanol concentrations were then switched between groups for a final 13 days. Ethanol intake increased for both groups over the first seven days and then reached asymptote. The daily intake (ml) of 5% ethanol was two times that of 10%, resulting in no difference between groups in g/kg ethanol consumed. When the concentrations were switched, g/kg/day dropped, but returned to previous levels within seven days. Again intake (ml) of 5% was two times that of 10% but groups did not differ in g/kg/day. Mean blood ethanol concentration at 9:30 hr was 75.0 mg/100 ml with 5% ethanol and 127.8 mg/100 ml with 10% ethanol. |
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Keywords: | Ethanol intake Schedule induced polydipsia Ethanol concentration Blood ethanol concentration |
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