Protective effect of lodoxamide tromethamine on allergen inhalation challenge |
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Authors: | Gavin D Watt Tiet C Bui Againdra K Bewtra Robert G Townley |
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Institution: | From Creighton University School of Medicine Omaha, Neb., USA |
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Abstract: | Lodoxamide tromethamine (U-42,585E) is a new drug intended for prophylaxis of mast cell-mediated allergic disease. It is a water-soluble, cromolyn-like agent with demonstrated activity in rat peritoneal mast cell assay, rat percutaneous anaphylaxis (rat PCA) and sensitized rhesus monkey airway system. Ten allergen-sensitive asthmatics were pretreated with lodoxamide (0.01, 0.1, or 1.0 mg) or placebo, then challenged with serial dilutions of allergen extract. Analysis of allergen dose-response curve parameters shows that pretreatment with lodoxamide offers significant protection against experimental allergen-induced bronchoconstriction. At 0.01 mg, lodoxamide was effective in over half the subjects tested. Administration of lodoxamide by inhalation at doses of 0.1 and 1.0 mg uniformly allowed subjects to tolerate significantly larger doses of inhaled allergen. Side effects observed at these doses were minimal. |
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Keywords: | Reprint requests to: Dr R G Townley Creighton University School of Medicine 2500 California St Omaha NE 68178 |
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