| NIDDM患者血小板Ca_(2+)转运及其与聚集功能的关系 |
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| 引用本文： | 蔡德鸿,刘宏,陈浩. NIDDM患者血小板Ca_(2+)转运及其与聚集功能的关系[J]. 南方医科大学学报, 1998, 0(3) |
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| 作者姓名： | 蔡德鸿 刘宏 陈浩 |
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| 作者单位： | 珠江医院内分泌科 |
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| 摘 要： | ３２例ＮＩＤＤＭ患者，分血小板聚集功能亢进组（ｎ＝１７）和无亢进组（ｎ＝１５），探讨Ｃａ２＋转运影响血小板胞浆游离Ｃａ２＋（［Ｃａ２＋］ｉ）变化与最大聚集（ＭＡＲ）的关系。结果：亢进组血小板静息［Ｃａ２＋］ｉ高于对照组（１３４．４±２６．４对１０１．５±１３．３ｎｍｏｌ／Ｌ，Ｐ＜０．０１）。［Ｃａ２＋］ｉ与ＭＡＲ呈正相关（ｒ＝０．３２１９，Ｐ＜０．０５）以凝血酶刺激，有胞外Ｃａ２＋内流及胞内Ｃａ２＋释放时，亢进组［Ｃａ２＋］ｉ高于对照组（９１８．９±２０７．６对７９１．２±１１９．６ｎｍｏｌ／Ｌ，Ｐ＜０．０１），并与ＭＡＲ呈正相关（ｒ＝０．３３７１，Ｐ＜０．０１）；以ＴＭＢ８阻滞胞内Ｃａ２＋释放，组间差异仍然显著（Ｐ＜０．０５）；当缺乏胞外Ｃａ２＋内流时，则组间不呈显著差异（Ｐ＞０．０５）。以钙载体Ａ２３１８７刺激，在有或无胞外Ｃａ２＋时，亢进组［Ｃａ２＋］ｉ均高于对照组（Ｐ均＜０．０５）然而，无亢进组上述各指标与对照组间均未呈显著差异。提示ＮＩＤＤＭ患者血小板聚集功能亢进与［Ｃａ２＋］ｉ变化有关，可能涉及胞浆内Ｃａ２＋稳态异常，凝血酶刺激胞外Ｃａ２＋内流及Ａ２３１８７作用胞内Ｃａ２＋释放增强等环节
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| 关 键 词： | 糖尿病；血小板；钙 |
Increased Ca~(2+ ) mobilization in patients with non insulin dependent diabetes mellitus with enhanced platelet aggregation |
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| Cai Dehong,Lui Hong,Chen Hao Deprmtnet of endocrinology,Zhujiang Hospital,First Military Medical Uiversity,Guangzhou. Increased Ca~(2+ ) mobilization in patients with non insulin dependent diabetes mellitus with enhanced platelet aggregation[J]. Journal of Southern Medical University, 1998, 0(3) |
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| Authors: | Cai Dehong Lui Hong Chen Hao Deprmtnet of endocrinology Zhujiang Hospital First Military Medical Uiversity Guangzhou |
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| Affiliation: | Cai Dehong,Lui Hong,Chen Hao Deprmtnet of endocrinology,Zhujiang Hospital,First Military Medical Uiversity,Guangzhou,510282 |
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| Abstract: | |
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| Keywords: | diabetes platelet aggregaton Ca 2+ mobilization |
| 本文献已被 CNKI 等数据库收录！ |
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