| Acute liver failure due to natural killer-like T-cell leukemia/ lymphoma： A case report and review of the Literature |
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| 作者姓名： | Dellon ES Morris SR Tang W Dunphy CH Russo MW |
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| 作者单位： | Department of Medicine University of North Carolina School of Medicine Chapel Hill,NC,United States,Department of Medicine University of North Carolina School of Medicine,Chapel Hill,NC,United States,Department of Pathology University of North Carolina School of Medicine,Chapel Hill,NC,United States,Department of Pathology University of North Carolina School of Medicine,Chapel Hill,NC,United States,Department of Medicine University of North Carolina School of Medicine,Chapel Hill,NC,United States |
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| 摘 要： | Acute liver failure (ALF) is a medical emergency requiring immediate evaluation for liver transplantation. We describe an unusual case of a patient who presented with ascites, jaundice, and encephalopathy and was found to have ALF due to natural killer (NK)-like T cell leukemia/lymphoma. The key immunophenotype was CD2 , CD3 , CD7 , CD56 . This diagnosis, which was based on findings in the peripheral blood and ascitic fluid, was confirmed with liver biopsy, and was a contraindication to liver transplantation. A review of the literature shows that hematologic malignancies are an uncommon cause of fulminant hepatic failure, and that NK-like T-cell leukemia/lymphoma is a relatively recently recognized entity which is characteristically CD3 and CD56 . This case demonstrates that liver biopsy is essential in diagnosing unusual causes of acute liver failure, and that infiltration of the liver with NK-like T-cell lymphoma/leukemia can cause acute liver failure.
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| 关 键 词： | 急性肝衰竭 T细胞 白血病 淋巴瘤 |
| 收稿时间： | 2005 Dec 12 |
Acute liver failure due to natural killer-like T-cell leukemia/lymphoma: a case report and review of the literature |
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| Dellon ES,Morris SR,Tang W,Dunphy CH,Russo MW.Acute liver failure due to natural killer-like T-cell leukemia/lymphoma: a case report and review of the literature[J].World Journal of Gastroenterology,2006,12(25):4089-4092. |
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| Authors: | Dellon Evan S Morris Shannon R Tang Wozhan Dunphy Cherie H Russo Mark W |
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| Institution: | 1. Department of Medicine, University of North Carolina School of Medicine,Chapel Hill, NC, United States
2. Department of Pathology,University of North Carolina School of Medicine, Chapel Hill,NC, United States |
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| Abstract: | Acute liver failure (ALF) is a medical emergency requiring immediate evaluation for liver transplantation. We describe an unusual case of a patient who presented with ascites, jaundice, and encephalopathy and was found to have ALF due to natural killer (NK)-like T cell leukemia/lymphoma. The key immunophenotype was CD2 , CD3 , CD7 , CD56 . This diagnosis, which was based on findings in the peripheral blood and ascitic fluid, was confirmed with liver biopsy, and was a contraindication to liver transplantation. A review of the literature shows that hematologic malignancies are an uncommon cause of fulminant hepatic failure, and that NK-like T-cell leukemia/lymphoma is a relatively recently recognized entity which is characteristically CD3 and CD56 . This case demonstrates that liver biopsy is essential in diagnosing unusual causes of acute liver failure, and that infiltration of the liver with NK-like T-cell lymphoma/leukemia can cause acute liver failure. |
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| Keywords: | Liver failure Liver transplant Nutaral killer cell |
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