Bench-to-bedside review: Inhaled nitric oxide therapy in adults |
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Authors: | Benedict C Creagh-Brown Mark JD Griffiths Timothy W Evans |
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Affiliation: | (1) Unit of Critical Care, Faculty of Medicine, Imperial College, London, UK;(2) Adult Intensive Care Unit, Royal Brompton Hospital, Sydney Street, SW6 NP London, UK |
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Abstract: | Nitric oxide (NO) is an endogenous mediator of vascular tone and host defence. Inhaled nitric oxide (iNO) results in preferential pulmonary vasodilatation and lowers pulmonary vascular resistance. The route of administration delivers NO selectively to ventilated lung units so that its effect augments that of hypoxic pulmonary vasoconstriction and improves oxygenation. This 'Bench-to-bedside' review focuses on the mechanisms of action of iNO and its clinical applications, with emphasis on acute lung injury and the acute respiratory distress syndrome. Developments in our understanding of the cellular and molecular actions of NO may help to explain the hitherto disappointing results of randomised controlled trials of iNO. |
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