| 草酸依地普仑的合成 |
| |
| 引用本文： | 姚忠科,阚丽娟. 草酸依地普仑的合成[J]. 中国新药杂志, 2006, 15(2): 117-120 |
| |
| 作者姓名： | 姚忠科 阚丽娟 |
| |
| 作者单位： | 1. 首都师范大学化学系,北京,100037
2. 中国科学院动物研究所,北京,100080 |
| |
| 摘 要： | 目的：合成草酸依地普仑。方法：以5-氰基苯酞为起始原料，经亲核加成、水解、化学拆分、环化和成盐等反应制得抗抑郁药草酸依地普仑。结果：以5-氰基苯酞计，总收率为13．6％。结论：该方法原料价廉易得，反应条件温和，操作简便，适合工业生产。
|
| 关 键 词： | 草酸依地普仑 5-HT选择性再摄取抑制剂 抗抑郁药 药物合成 |
| 文章编号： | 1003-3734（2006）02-0117-04 |
| 收稿时间： | 2005-07-19 |
| 修稿时间： | 2005-07-19 |
Synthesis of escitalopram oxadate |
| |
| YAO Zhong-ke,KAN Li-juan. Synthesis of escitalopram oxadate[J]. Chinese Journal of New Drugs, 2006, 15(2): 117-120 |
| |
| Authors: | YAO Zhong-ke KAN Li-juan |
| |
| Affiliation: | 1 Department of Chemistry, Capital Normal University, Beijing 100037, China; 2 Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China |
| |
| Abstract: | Objective:To synthesize escitalopram oxalate. Methods:Starting from 5-cyanophthalide, escitalopram oxalate was prepared via several steps including nucleophilic addition, hydrolysis, chemical separation, cyclization and salt formation. Results:A total yield of escitalopram oxalate was 13. 6% . Conclusion:This easily manipulated synthetic process is worthy to have further pilot manufacture. |
| |
| Keywords: | escitalopram oxadate selective serotonin reuptake inhibitor (SSRI) antidepressant synthesis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
