前列腺癌患者血清IGF-I、PRL及SE-cad测定的临床意义

目的：探讨前列腺癌患者血清IGF-Ⅰ、PRL及SE-cad水平的变化及临床意义。方法：血清IGF-Ⅰ采用放射免疫分析;fPSA及PRL采用化学发光法;血清SE-cad采用酶联免疫分析法。结果：前列腺增生组患者血清IGF-Ⅰ水平较对照组升高显著（P〈0.05）;血清PRL含量也较对照组显著升高（P〈0.05）;SE-cad浓度其测定数值也存在显著性差异（P〈0.05）。而前列腺癌患者组血清IGF-Ⅰ水平较对照组升高更为显著（P〈0.01）;血清PRL含量也较对照组升高极其显著（P〈0.01）;SE-cad浓度其测定数值升高同样非常显著（P〈0.01）。灵敏度分析表明,fPSA＋IGF-Ⅰ和fPSA＋SE-cad两组灵敏度显著高于fPSA单项测定组;fPSA＋PRL组灵敏度略低,但P〉0.05。特异性分析则fPSA＋SE-cad组fPSA单项测定组显著增高（P〈0.05）,fP-SA＋PRL降低明显,fPSA＋IGF-Ⅰ组与单项组差异并不显著（P〉0.05）。结论：血清IGF-Ⅰ、PRL及SE-cad水平的变化与前列腺癌的发生关系密切,与fPSA的联合测定可提高诊断的灵敏度及特异性,有助于前列腺癌的辅助诊断。

Clinical Significance of Determination of Serum IGF-I,PRL and SE -cad Levels in Patients with Prostatic Carcinoma

Objective To study the clinical significance of determination of changes of serum IGF-I , PRL and SE - cad levels in patients withprostatie cancer. Methods Serum IGF-I（with RIA）, fPSA, PRL （with CLIA） andSE-ead （with ELISA） levels were determined in 34 patients with prostatic cancer, 34 patients with BPH, and 35 controls. Results Serum IGF-I , fPSA, PRL and SE-cad levels in the patients with BPH were significantly higher than those in the controls（P〈0.05）, the levels in patients with prostatic cancer were even higher with respect to the diagnostic sensitivity both the sensitivity of combined determination of fPSA＋IGF-I and fPSA ＋ SE-cad were significantly higher than that of single fPSA determination. Combined determination of fPSA ＋ PIlL yielded a not significantly lower sensitivity than that with single fPSA （ P 〉 0.05）. For specificity, fPSA ＋ SE-cad was signifieandy more specific （P 〉 0.05 ）, fPSA ＋ IGF-I was more specific but not significantly, but fPSA ＋ PRL was significantly lessspecifie. Conclusion Combined determination of serum fPSA with IGF-I,SE-cad could improve the diagnostic aecurary and specificity in patients with prostatic cancer.