Influence of the two-stage anatomic correction of simple transposition of the great arteries on left ventricular function |
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| Authors: | H H Sievers P E Lange D G Onnasch R Radley-Smith M H Yacoub P H Heintzen D Regensburger A Bernhard |
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| Affiliation: | 1. From the Departments of Cardiovascular Surgery and Pediatric Cardiology of the University of Kiel, Kiel, Federal Republic of Germany;2. Harefield Hospital, Harefield, Great Britain;1. Department of Crop Genetics, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK;2. Department of Plant Pathology, University of California, Davis, CA, 95616, USA;3. Department of Plant Pathology and Plant-Microbe Biology, Cornell University, Ithaca, NY 14853, USA;4. Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720, USA;5. UMR 1332 Biologie du Fruit et Pathologie, Univ. Bordeaux, INRAE, Villenave d''Ornon 33882 France;6. Boyce Thompson Institute, Ithaca, NY 14853, USA;7. Emerging Pests and Pathogens Research Unit, Robert W. Holley Center, USDA ARS, Ithaca, NY 14853, USA;8. School of Environmental Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK;1. Department of Geoscience Engineering, Arak University of Technology, Arak, Iran;2. Department of Civil Engineering, Islamic Azad University of Khoy, Khoy, Iran;1. School of Civil and Transportation Engineering, Hebei University of Technology, Tianjin, 300401, China;2. College of Geology Engineering and Geomatics, Chang′an University, Xi′an, 710054, China;1. Division of HIV/AIDS Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, United States;2. Indiana University-Purdue University Indianapolis, Indianapolis, IN, United States;3. Indiana State Department of Health, Indianapolis, IN, United States;4. Division of Global HIV & TB, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA, United States;5. Indiana University Richard M. Fairbanks School of Public Health, Indianapolis, IN, United States;6. Division of Viral Hepatitis, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, United States;1. Fatima College of Health Sciences, Institute of Applied Technology, Abu Dhabi, United Arab Emirates;2. Department of Applied Sciences and Mathematics, Abu Dhabi University, Abu Dhabi, United Arab Emirates;3. Department of Applied Physics and Astronomy, University of Sharjah, Sharjah, United Arab Emirates;4. Institute for Quantum Science and Engineering, Texas A&M University, College Station, TX 77843, USA;1. Department of Physical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur 741246, West Bengal, India |
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| Abstract: | To evaluate the influence of the 2-stage anatomic correction of simple transposition of the great arteries on left ventricular (LV) function, pressure and angiocardiographic volume data were analyzed during resting conditions shortly before banding of the pulmonary trunk (n = 12) and before (n = 17) and after anatomic correction (n = 11), and compared with data from controls (n = 12). Age at banding and anatomic correction was between 1 and 44 months (mean 16 +/- 10) and between 13 and 47 months (mean 24 +/- 10), respectively. The interval between anatomic correction and the investigation ranged from 10 to 29 months (mean 20 +/- 7). After banding, LV ejection fraction decreased (p less than 0.01) and LV peak systolic pressure (p less than 0.01) as well as LV end-diastolic pressure (p less than 0.05) increased. After anatomic correction, these variables and LV end-systolic wall stress were not significantly different from control values. The LV end-systolic wall stress-ejection fraction relation in 7 of 11 patients after anatomic correction was within control range. The highest values were found in the youngest patients at banding and at anatomic correction. In contrast to measures of global myocardial function, such as LV ejection fraction and LV end-diastolic pressure data, the LV end-systolic stress-ejection fraction relation suggest that LV function may not be normal in some patients 20 months after anatomic correction. Young age at operation, however, appears to be advantageous in preserving LV function. Hemodynamic alterations after banding probably reflect LV adaptation to systemic pressures in a hypoxemic circulation. |
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